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Please use this identifier to cite or link to this item: http://hdl.handle.net/1842/826

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Title: Immunity Promotes Virulence Evolution in a Malaria Model
Authors: Mackinnon, Margaret J
Read, Andrew F
Issue Date: 2004
Citation: Mackinnon MJ, Read AF (2004) Immunity promotes virulence evolution in a malaria model. PLoS Biol 2(9): e230.
Publisher: PLoS Biology
Abstract: Evolutionary models predict that host immunity will shape the evolution of parasite virulence. While some assumptions of these models have been tested, the actual evolutionary outcome of immune selection on virulence has not. Using the mouse malaria model, Plasmodium chabaudi, we experimentally tested whether immune pressure promotes the evolution of more virulent pathogens by evolving parasite lines in immunized and nonimmunized (‘‘naive’’) mice using serial passage. We found that parasite lines evolved in immunized mice became more virulent to both naive and immune mice than lines evolved in naive mice. When these evolved lines were transmitted through mosquitoes, there was a general reduction in virulence across all lines. However, the immune-selected lines remained more virulent to naive mice than the naive-selected lines, though not to immunized mice. Thus, immune selection accelerated the rate of virulence evolution, rendering parasites more dangerous to naı¨ve hosts. These results argue for further consideration of the evolutionary consequences for pathogen virulence of vaccination.
Keywords: PI
postinfection
I-line
immune-selected line
naive-selected line
N-line
URI: DOI: 10.1371/journal.pbio.0020230
http://hdl.handle.net/1842/826
Appears in Collections:Biological Sciences publications

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