Now showing items 1-20 of 1843

  • Systems redox biology analysis of cancer 

    Johnston, Hannah Elizabeth (The University of Edinburgh, 2018-07-09)
    The Warburg effect describes the survival advantage of cancer cells in that they can proliferate under low oxygen/hypoxic conditions via a less efficient pathway known as glycolysis. It has not yet been documented at ...
  • Synthesis and characterisation of novel functional phthalocyanine nano-porous materials 

    Burt, Luke Anthony (The University of Edinburgh, 2018-07-09)
    This project was focused on the synthesis of novel phthalocyanines for the construction of porous molecular crystals that incorporate the desirable properties associated with phthalocyanine complexes. Conventional ...
  • Structural studies of salt hydrates for heat-storage applications 

    Clark, Rowan Elizabeth (The University of Edinburgh, 2018-07-09)
    Salt hydrates have the potential to be used in heat storage as both phase-change materials (PCMs) and thermochemical materials (TCMs). These materials offer advantages over traditional heat storage methods due to their ...
  • Selective modification of biomolecules using radical mediated hydrothiolation chemistry 

    Georgiev, David Georgiev (The University of Edinburgh, 2018-07-09)
    Intracellular protein-protein interactions (PPI’s) play a vital role in many biological processes. Although they are viewed as of high biological interest they prove difficult to explore as potential targets for drug ...
  • Rational ligand design to support reactive main-group compounds 

    Urwin, Stephanie Jane (The University of Edinburgh, 2018-07-09)
    The chemistry of the tetrameric low-valent aluminium compoud (Cp*Al)4 (Cp* = 1,2,3,4,5- pentamethylcyclopentadienyl) is relatively undeveloped compared to its monomeric cousin dippNacNacAl (dippNacNac = 2,6-diisopropyl ...
  • Photophysical characterisation of novel fluorescent base analogues 

    Fisher, Rachel Sarah (The University of Edinburgh, 2018-07-09)
    Fluorescent nucleic acid base analogues (FBAs) are an important class of molecule used to study the structure and dynamics of DNA and RNA. These base analogues are molecules with structures that resemble one of the natural ...
  • Ordering phenomena in iron-containing spinels 

    Perversi, Giuditta (The University of Edinburgh, 2018-07-09)
    The spinel structure (general formula AB2O4) is widely occurring in natural and synthetic materials, and has a marked technological and scientific significance due to its magnetic, electric and multiferroic behaviours. ...
  • NMR and in silico studies of fucosylated chondroitin sulfate (fCS) and its interactions with selectins 

    Brodaczewska, Natalia Anna (The University of Edinburgh, 2018-07-09)
    This thesis describes structural studies on the interactions between the fucosylated chondroitin sulfate (fCS) oligosaccharides and human proteins known as selectins. fCS is a carbohydrate obtained from sea cucumbers, ...
  • Luminescence-based optical sensors towards in vivo analysis 

    Mohamad, Mohd Fuad Bin (The University of Edinburgh, 2018-07-09)
    Continuous monitoring of physiological parameters such as pH and oxygen (O2) are of great importance in determining the health status of a patient. Arterial blood gas analysis is a current clinical method used to measure ...
  • High pressure synthesis and neutron diffraction studies of new magnetic manganites 

    McNally, Graham Michael (The University of Edinburgh, 2018-07-09)
    With the discovery of appreciable room temperature magnetoresistance (MR) in high Curie temperature (Tc) ferrimagnetic double perovskites such as Sr2FeMoO6, research surrounding other materials of this type has expanded. ...
  • Bimetallic actinide complexes for small molecule activation 

    Wells, Jordann Ashley Logan Slovenne Denis (The University of Edinburgh, 2018-07-09)
    The work described in this thesis concerns the synthesis of actinide complexes and their reactivity towards small unsaturated molecules. Complexes bearing tetraphenoxide, borohydride and boroxide ligands have been ...
  • High-resolution Fourier transform ion cyclotron resonance mass spectrometry and nuclear magnetic resonance spectroscopy of humic substances 

    Blackburn, John William Teasdale (The University of Edinburgh, 2018-07-09)
    Humic substances (HS) are described as a complex mixture of organic molecules formed by incomplete decomposition of plant, animal and microbial matter. They are found in soil, water and air and have many environmental ...
  • Development of Halomethyl-Triazole reagents for installation of protein post-translational modification mimics 

    Brewster, Richard Christian (The University of Edinburgh, 2018-07-09)
    Triazoles have been widely used as amide bond isosteres in chemical biology as linkers and to enhance proteolytic stability. The use of triazoles has grown exponentially since the discovery of the copper (I) catalysed ...
  • Developing Earth-abundant metal-catalysts for hydrofunctionalisation 

    Paliga, James Francis (The University of Edinburgh, 2018-07-09)
    The iron-catalysed hydromagnesiation of styrene derivatives has been developed further from previous publications, expanding the electrophile scope to enable the regioselective formation of new carbon-carbon and ...
  • Exploiting anionically-tethered N-heterocyclic carbene complexes for small molecule activation 

    McMullon, Max William (The University of Edinburgh, 2018-07-09)
    N-heterocyclic carbenes (NHCs) can be used as ligands for organometallics complexes, which can then facilitate numerous catalytic applications, such as, C-H activation, small molecule activation and numerous materials ...
  • Developing dynamic combinatorial chemistry as a platform for drug discovery 

    Ekström, Alexander Gösta (The University of Edinburgh, 2018-07-09)
    Dynamic combinatorial chemistry (DCC) is a powerful tool to identify new ligands for biological targets. In the technique, library synthesis and hit identification are neatly combined into a single step. A labile ...
  • Designing reagents for the solvent extraction of critical metal resources 

    Doidge, Euan Douglas (The University of Edinburgh, 2018-07-09)
    The work in this thesis aims to develop new systems for the more efficient recovery of metals from aqueous solution using solvent extraction. Understanding the underlying coordination chemistry to improve hydrometallurgical ...
  • DNA-based logic 

    Bader, Antoine (The University of Edinburgh, 2018-07-09)
    DNA nanotechnology has been developed in order to construct nanostructures and nanomachines by virtue of the programmable self-assembly properties of DNA molecules. Although DNA nanotechnology initially focused on spatial ...
  • 2D and 3D applications of polymeric biomaterials 

    Venturato, Andrea (The University of Edinburgh, 2018-07-09)
    The field of biomaterials has seen huge development over the past decade with enormous efforts invested in discovering materials with improved biocompatibility, application and versatility. Polymers can display many ...
  • Biochemical and biophysical investigations into key malaria parasite proteins 

    Weir, Christopher Neil; Haggarty-Weir, Christopher Neil (The University of Edinburgh, 2018-07-09)
    Plasmodium falciparum, the most pestilential of the malaria parasite species, is responsible for ~450,000 direct deaths annually. Clinical disease is a consequence of the blood stage of the parasite’s lifecycle involving ...