Now showing items 1-20 of 1714

  • Biochemical and biophysical investigations into key malaria parasite proteins 

    Weir, Christopher Neil; Haggarty-Weir, Christopher Neil (The University of Edinburgh, 2018-07-09)
    Plasmodium falciparum, the most pestilential of the malaria parasite species, is responsible for ~450,000 direct deaths annually. Clinical disease is a consequence of the blood stage of the parasite’s lifecycle involving ...
  • Applications of tetrazines in chemical biology 

    Neumann, Kevin (The University of Edinburgh, 2018-07-09)
    The need for chemoselective bond formation within complex biological systems has driven much research in chemical biology and chemical medicine and has allowed control over the structure and biological properties of a ...
  • Advancements and understanding of Blister-Based Laser-Induced Forward-Transfer 

    Goodfriend, Nathan Thomas (The University of Edinburgh, 2018-07-09)
    Blister-Based Laser-Induced Forward-Transfer (BB LIFT) is a new method of particle transfer, capable of projecting complex and fragile particles into the gas phase. The technique uses a laser pulse to deform a metal or ...
  • Transition metal catalysis: a new paradigm in bioorthogonal drug activation 

    Clavadetscher, Jessica Veronica (The University of Edinburgh, 2017-11-30)
    Powerful tools have emerged in the past few years to allow the sensing, imaging and modulation of biological processes in living systems. Bioorthogonal organometallic reactions are transformations catalysed by transition ...
  • Total synthesis of phenolic natural products 

    De Silvestro, Irene (The University of Edinburgh, 2017-11-30)
    This thesis is regarded with the biomimetic total synthesis of phenolic natural products and describes two different projects. Chapter 1 introduces phenolic natural products, the most important biosynthetic pathways for ...
  • Use of acetylacetonate‐based paramagnetic metalloligands in the construction of supramolecular magnetic coordination capsules 

    O'Connor, Helen (The University of Edinburgh, 2018-07-09)
    In molecular magnetism, rational design and serendipity have played complementary roles in the synthesis of complexes which display a breadth of interesting physical characteristics. These range from the basic understanding ...
  • Tailoring the physical properties of energetic materials 

    Ward, Daniel W. (The University of Edinburgh, 2017-11-30)
    Energetic materials are a class of material that have large amounts of chemical energy stored within their molecular structure. This energy is released upon decomposition, generally in the form of rapidly expanding, hot ...
  • Evolution of restriction-modification systems 

    Bower, Edward Kenneth Merrick (The University of Edinburgh, 2017-07-07)
    Restriction Modification (R-M) systems prevent the invasion of foreign genetic material into bacterial cells and are therefore important in maintaining the integrity of the host genome. The spread of antibiotic resistance, ...
  • Effect of guest uptake and high pressure on Zn- and Zr- metal-organic frameworks 

    Hobday, Claire Louise (The University of Edinburgh, 2017-07-07)
    Porous materials are essential to our everyday lives, for example as an effective catalyst in the cracking of crude oil, or as water softeners in washing powder. When developing novel functional porous materials, it is ...
  • Synthesis, characterisation and reactivity study of rare earth metal complexes 

    Wang, Kai (The University of Edinburgh, 2018-07-09)
    The chapter one introduces the reported examples of rare earth metal (RE) complexes with different oxidation states. It also reviews the synthesis and reactivity study of N-heterocyclic carbene (NHC) supported transition ...
  • Photophysical studies of 2-Aminopurine in DNA 

    McKenzie, Grant (The University of Edinburgh, 2017-07-07)
    Deoxyribonucleic acid (DNA) forms the basis of all known living organisms. Despite the essential role played by DNA, its dynamic system and functional behaviour are still not completely understood. The work presented in ...
  • Intensification of industrial processes: auto-tandem and molecular weight enlarged catalysis 

    Fenton, Lewis Michael (The University of Edinburgh, 2018-07-09)
    The chemical industry is an essential part of modern society and therefore has a responsibility to develop solutions for the problems facing it. A major problem is continuing to match the material demands of a growing ...
  • Polymer microarrays for biomedical applications 

    Simmonte Owens, Matthew John (The University of Edinburgh, 2017-07-07)
    Biocompatible polymers are used exhaustively within the biomedical arena, demonstrating a mechanical and chemical diversity that few other materials possess. As polymer technologies evolves to cater for new medical ...
  • Actinide Hydrocarbyl chemistry supported by a small flexible pyrrolic macrocycle 

    Suvova, Marketa (The University of Edinburgh, 2018-07-09)
    Thorium(IV) and uranium(IV) coordination complexes have been studied for the last 60 years. They have shown interesting reactivity that is often divergent from that of transition metal complexes, and that also provides ...
  • Methanoanthracene-based polymers of intrinsic microporosity for membrane applications 

    Williams, Rhodri John (The University of Edinburgh, 2017-07-07)
    Polymers were synthesised containing the methanoanthracene (MA), methanopentacene (MP) and benzomethanoanthracene (BzMA) units to investigate their properties as gas separation membranes. For each monomer type, polymers ...
  • High-resolution structural studies of Kynurenine 3-Monooxygenase 

    Taylor, Mark Robert Duncan (The University of Edinburgh, 2018-07-09)
    The kynurenine pathway produces NAD+ from L-tryptophan. Metabolites known as the kynurenines are produced within the pathway. The effects of the kynurenines have been associated with a number of diseases including cancer, ...
  • Optical probes for enhanced targeting of cancer 

    García Guzmán, Claudia María (The University of Edinburgh, 2017-11-30)
    The diagnosis of cancer in early stages is an unmet clinical need, especially in view that current treatments for cancer cannot address metastatic disease. Cancer aberration processes are associated to an increase in the ...
  • Modification of poly(lactic acid) via Olefin cross-metathesis 

    Sinclair, Fern (The University of Edinburgh, 2017-11-30)
    Poly(lactic acid), PLA, is a viable replacement to petroleum derived polymers due to its renewable feedstock, biodegradability and bioassimilability, yet improvements in its physical, thermal and mechanical properties ...
  • Detection of miRNA by SMART technology 

    Sailis, Fiammetta (The University of Edinburgh, 2017-11-30)
    Aberrant expression of short non-coding micro RNAs (miRNA) in many human diseases, along with remarkable stability in physiological media, has made them attractive clinical biomarkers. In particular, miRNA-122 is ...
  • Complexes of Schiff-base macrocycles and donor-expanded dipyrrins for catalysis and uranyl reduction 

    Pankhurst, James Richard (The University of Edinburgh, 2018-07-09)
    The modern world faces a number of challenges related to energy and the environment. Atmospheric levels of carbon dioxide have now surpassed the 400 ppm mark due to the burning of fossil fuels, yet despite its abundance ...