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dc.contributor.authorRiedel, G
dc.contributor.authorMicheau, J
dc.contributor.authorLam, A G M
dc.contributor.authorRoloff, E.v.L.
dc.contributor.authorMartin, Stephen J
dc.contributor.authorBridge, H
dc.contributor.authorde Hoz, L
dc.contributor.authorPoeschel, B
dc.contributor.authorMcCulloch, J
dc.contributor.authorMorris, Richard G M
dc.coverage.spatial8en
dc.date.accessioned2005-03-17T15:42:01Z
dc.date.available2005-03-17T15:42:01Z
dc.date.issued1999-10
dc.identifier.citationRiedel G, Micheau J, Lam AGM, Roloff EV, Martin SJ, Bridge H, de Hoz L, Poeschel B, McCulloch J, Morris RGM, NATURE NEUROSCIENCE, 2 (10): 898-905 OCT 1999en
dc.identifier.urihttp://neurosci.nature.com
dc.identifier.urihttp://hdl.handle.net/1842/738
dc.description.abstractStudies of patients and animals with brain lesions have implicated the hippocampal formation in spatial, declarative/relational and episodic types of memory. These and other types of memory consist of a series of interdependent but potentially dissociable memory processes—encoding, storage, consolidation and retrieval. To identify whether hippocampal activity contributes to these processes independently, we used a novel method of inactivating synaptic transmission using a water-soluble antagonist of AMPA/kainate glutamate receptors. Once calibrated using electrophysiological and two-deoxyglucose techniques in vivo, drug or vehicle was infused chronically or acutely into the dorsal hippocampus of rats at appropriate times during or after training in a water maze. Our findings indicate that hippocampal neural activity is necessary for both encoding and retrieval of spatial memory and for either trace consolidation or long-term storage.en
dc.format.extent218340 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherNature Publishing Groupen
dc.subjectkainate glutamate receptorsen
dc.subjectneuralen
dc.subjecthippocampusen
dc.subjectmemoryen
dc.titleReversible neural inactivation reveals hippocampal particin several memory processesipationen
dc.typeArticleen


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