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dc.contributor.authorSnaith, Hilary A
dc.contributor.authorSawin, Ken
dc.coverage.spatial5en
dc.date.accessioned2005-02-22T16:01:18Z
dc.date.available2005-02-22T16:01:18Z
dc.date.issued2003-06-05
dc.identifier.citation"Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips" Snaith HA, Sawin KE. NATURE, 423 (6940): 647-651 JUN 5 2003en
dc.identifier.uridoi:10.1038/nature01672
dc.identifier.urihttp://www.nature.com/nature
dc.identifier.urihttp://hdl.handle.net/1842/713
dc.description.abstractMicrotubules have a central role in eukaryotic cell polarity1, in part through interactions between microtubule end-binding proteins and the cell cortex2,3. In the fission yeast Schizosaccharomyces pombe, microtubules and the polarity modulator tea1p maintain cylindrical cell shape and strictly antipodal cell growth4–7. The tea1p protein is transported to cell tips by association with growing microtubule plus ends8; once at cell tips, tea1p releases from microtubule ends and associates with the cell cortex, where it coordinates polarized growth4,6. Here we describe a cortical protein, mod5p, that regulates the dynamic behaviour of tea1p. In mod5D cells, tea1p is efficiently transported on microtubules to cell tips but fails to anchor properly at the cortex and thus fails to accumulate to normal levels. mod5p contains a signal for carboxy-terminal prenylation and in wildtype cells is associated with the plasma membrane at cell tips. However, in tea1D cells, although mod5p remains localized to the plasma membrane, mod5p is no longer restricted to the cell tips. We propose that tea1p and mod5p act in a positive-feedback loop in the microtubule-mediated regulation of cell polarity.en
dc.format.extent317931 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherNature Publishing Groupen
dc.subjectMicrotubulesen
dc.subjectSchizosaccharomyces pombeen
dc.subjecttea1pen
dc.subjectmod5pen
dc.titleFission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tipsen
dc.typeArticleen


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