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Please use this identifier to cite or link to this item: http://hdl.handle.net/1842/711

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Title: Imperfect vaccines and the evolution of pathogen virulence
Authors: Gandon, Sylvain
Mackinnon, Margaret J
Nee, Sean
Read, Andrew F
Issue Date: 13-Dec-2001
Citation: Imperfect vaccines and the evolution of pathogen virulence Gandon S, Mackinnon MJ, Nee S, Read AF NATURE 414 (6865): 751-756 DEC 13 2001
Publisher: Nature Publishing Group
Abstract: Vaccines rarely provide full protection from disease. Nevertheless, partially effective (imperfect) vaccines may be used to protect both individuals and whole populations.We studied the potential impact of different types of imperfect vaccines on the evolution of pathogen virulence (induced host mortality) and the consequences for public health. Here we show that vaccines designed to reduce pathogen growth rate and/or toxicity diminish selection against virulent pathogens. The subsequent evolution leads to higher levels of intrinsic virulence and hence to more severe disease in unvaccinated individuals. This evolution can erode any population-wide benefits such that overall mortality rates are unaffected, or even increase, with the level of vaccination coverage. In contrast, infection-blocking vaccines induce no such effects, and can even select for lower virulence. These findings have policy implications for the development and use of vaccines that are not expected to provide full immunity, such as candidate vaccines for malaria.
Keywords: Vaccines
pathogen
virulence
malaria
URI: doi:10.1038/414751a
http://www.nature.com/nature
http://hdl.handle.net/1842/711
Appears in Collections:Biological Sciences publications

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