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dc.contributor.authorDeary, Ian J
dc.contributor.authorWhiteman, Martha C
dc.contributor.authorPattie, Alison
dc.contributor.authorStarr, John M
dc.contributor.authorHayward, Caroline
dc.contributor.authorWright, Alan F
dc.contributor.authorCarothers, Andrew
dc.contributor.authorWhalley, Lawrence J
dc.coverage.spatial2en
dc.date.accessioned2005-02-16T12:22:25Z
dc.date.available2005-02-16T12:22:25Z
dc.date.issued2002-08-29
dc.identifier.citationDeary IJ, Whiteman MC, Pattie A, Starr JM, Hayward C, Wright AF, Carothers A, Whalley LJ, NATURE, 418 (6901): 932-932 AUG 29 2002en
dc.identifier.urihttp://www.nature.com/
dc.identifier.urihttp://hdl.handle.net/1842/702
dc.description.abstractThere is a marked variation in whether people retain sufficient cognitive function to maintain their quality of life and independence in old age, even among those without dementia, so it would be valuable to identify the determinants of normal age-related cognitive change (1,2). We have retested non-demented 80-year-olds who were participants in the Scottish Mental Survey of 1932, and find that the variation in their non-pathological cognitive change from age 11 to 80 is related to their apolipoprotein E (APOE) genotype. This effect of the APOEe4 allele on normal cognitive ageing may be mediated by a mechanism that is at least partly independent of its predisposing effect towards Alzheimer’s disease.en
dc.format.extent139792 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherNature Publishing Groupen
dc.subjectCognitiveen
dc.subjectapolipoprotein Een
dc.subjectAPOEe4en
dc.subjectalleleen
dc.subjectageingen
dc.subjectdementiaen
dc.subjectdementeden
dc.subjectAlzheimer’s diseaseen
dc.titleAgeing: Cognitive change and the APOEe4 alleleen
dc.typeArticleen


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