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dc.contributor.authorBachtrog, Doris
dc.contributor.authorCharlesworth, Brian
dc.coverage.spatial4en
dc.date.accessioned2005-02-09T17:16:09Z
dc.date.available2005-02-09T17:16:09Z
dc.date.issued2002-03-21
dc.identifier.citationBachtrog D, Charlesworth B, NATURE, 416 (6878): 323-326 MAR 21 2002en
dc.identifier.urihttp://hdl.handle.net/1842/693
dc.description.abstractSex chromosomes are generally believed to have descended from a pair of homologous autosomes. Suppression of recombination between the ancestral sex chromosomes led to the genetic degeneration of the Y chromosome1. In response, the X chromosome may become dosage-compensated1,2. Most proposed mechanisms for the degeneration of Y chromosomes involve the rapid fixation of deleterious mutations on the Y1. Alternatively, Y-chromosome degeneration might be a response to a slower rate of adaptive evolution, caused by its lack of recombination3. Here we report patterns of DNA polymorphism and divergence at four genes located on the neo-sex chromosomes of Drosophila miranda. We show that a higher rate of protein sequence evolution of the neo- X-linked copy of Cyclin B relative to the neo-Y copy is driven by positive selection, which is consistent with the adaptive hypothesis for the evolution of the Y chromosome3. In contrast, the neo- Y-linked copies of even-skipped and roundabout show an elevated rate of protein evolution relative to their neo-X homologues, probably reflecting the reduced effectiveness of selection against deleterious mutations in a non-recombining genome1.Our results provide evidence for the importance of sexual recombination for increasing and maintaining the level of adaptation of a population.en
dc.format.extent178304 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherNature Publishing Groupen
dc.subjectReduceden
dc.subjectAdaptationen
dc.subjectnon-recombiningen
dc.subjectneo-Yen
dc.subjectchromosomeen
dc.subjectDrosophila mirandaen
dc.titleReduced adaptation of a non-recombining neo-Y chromosomeen
dc.typeArticleen


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