Now showing items 1-6 of 6
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
(© 1998 by Cold Spring Harbor Laboratory Press, 1998)
The propagation of embryonic stem (ES) cells in an undifferentiated pluripotent state is dependent on leukemia inhibitory factor (LIF) or related cytokines. These factors act through receptor complexes containing the ...
Phenotypic Complementation Establishes Requirements for Specific POU Domain and Generic Transactivation Function of Oct-3/4 in Embryonic Stem Cells
(Copyright © 2002, American Society for Microbiology. All Rights Reserved., 2001)
Transcription factors of the POU family govern cell fate through combinatorial interactions with coactivators and corepressors. The POU factor Oct-3/4 can define differentiation, dedifferentation, or self-renewal of pluripotent ...
Changing potency by spontaneous fusion
(Nature Publishing Group, 2002-04-04)
Recent reports have suggested that mammalian stem cells residing in one tissue may have the capacity to produce differentiated cell types for other tissues and organs (1–9). Here we define a mechanism by which progenitor ...
Functional gene screening in embryonic stem cell implicates Wnt antagonism in neural differentiation.
(Nature Publishing Group, 2002)
The multilineage differentiation capacity of mouse embryonic stem (ES) cells offers a potential testing platform for gene products that mediate mammalian lineage determination and cellular specialization. Identification ...
Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells.
Embryonic stem (ES) cells undergo extended proliferation while remaining poised for multilineage differentiation. A unique network of transcription factors may characterize self-renewal and simultaneously suppress ...
Self-renewal of teratocarcinoma and embryonic stem cells
(Nature Publishing Group, 2004)
Pluripotent stem cells derived from preimplantation embryos, primordial germ cells or teratocarcinomas are currently unique in undergoing prolonged symmetrical self-renewal in culture. For mouse embryonic stem (ES)cells, ...