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Full-length-enriched cDNA libraries from Echinococcus granulosus contain separate populations of oligo-capped and trans-spliced transcripts and a high level of predicted signal peptide sequences
The tissue-dwelling larval stages of the cestode Echinococcus granulosus are intimately associated with the host, implying that a range of molecular mediators may be secreted by the parasite into the host environment. ...
Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing
(Elsevier Science, 2001)
While interference with the class I MHC pathway by homologous to pathogen-encoded gene products, especially those of viruses, has been well documented, few examples type 2 cystatins were recently identified. Their ...
Immune evasion genes from filarial nematodes
Helminth parasites have large genomes (~108 bp) which are likely to encode a spectrum of products able to block or divert the host immune response. We have employed three parallel approaches to identify the first generation ...
Expression and immune recognition of Brugia malayi VAL-1, a homologue of vespid venom allergens and Ancylostoma secreted proteins
Several important nematode parasites have been found to express members of a gene family variously termed as venom allergen antigen homologue (vah) or Ancylostoma secreted protein (asp). In some cases these products are ...
Abundant larval transcript-1 and -2 genes from Brugia malayi : diversity of genomic environments but conservation of 5ı promoter sequences functional in Caenorhabditis elegansı
The genomic organisation of two abundant larval transcript (alt) genes from the filarial nematode Brugia malayi has been defined. The products of these genes are 78% identical in amino acid sequence, and are highly expressed ...