Now showing items 1-8 of 8
Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice
(AMER ASSOC ADVANCEMENT SCIENCE, WASHINGTON, 2002)
The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove thymine (T) or uracil (U) from a mismatched CpG site in vitro. These properties suggest that MBD4 might function in vivo to ...
Absence of genome-wide changes in DNA methylation during development of the zebrafish
(Nature Publishing, 1999-10)
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
(Nature Publishing Group, 1999-09)
Mammalian DNA is methylated at many CpG dinucleotides. The biological consequences of methylation are mediated by a family of methyl-CpG binding proteins (1–4). The best characterized family member is MeCP2, a transcriptional ...
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
(Nature Publishing Group, 2001-03)
Rett syndrome (RTT) is an inherited neurodevelopmental disorder of females that occurs once in 10,000–15,000 births1,2. Affected females develop normally for 6–18 months, but then lose voluntary movements, including ...
The methylated component of the Neurospora crassa genome
(Nature Publishing Group, 2003-04-24)
Cytosine methylation is common, but not ubiquitous, in eukaryotes. Mammals (1) and the fungus Neurospora crassa (2,3) have about 2–3% of cytosines methylated. In mammals, methylation is almost exclusively in the ...
MeCP2 Repression Goes Nonglobal
(AMER ASSOC ADVANCEMENT SCIENCE, WASHINGTON, 2003)
Methylation of CpG islands in gene promoters results in silencing of those genes. Mutation of a methyl-CpG binding domain protein called MeCP2 that contributes to the maintenance of methylation-mediated gene silencing is ...
Vestiges of a DNA methylation system in Drosophila melanogaster?
(Nature Publishing Group, 1999-11)
Molecular biology - Methylation talk between histones and DNA
(AMER ASSOC ADVANCEMENT SCIENCE, WASHINGTON, 2001)
The addition of methyl groups to DNA or histones is a way to directly or indirectly silence gene expression. Although the two events are conceivably connected, they have always been studied separately. In his Perspective, ...