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dc.contributor.authorByrne, Mary E
dc.contributor.authorBarley, Ross
dc.contributor.authorCurtis, Mark
dc.contributor.authorArroyo, Juana Maria
dc.contributor.authorDunham, Maitreya
dc.contributor.authorHudson, Andrew
dc.contributor.authorMartienssen, Robert A
dc.coverage.spatial5en
dc.date.accessioned2005-02-08T17:10:54Z
dc.date.available2005-02-08T17:10:54Z
dc.date.issued2000-12-21
dc.identifier.citationByrne ME, Barley R, Curtis M, Arroyo JM, Dunham M, Hudson A, Martienssen RA, NATURE, 408 (6815): 967-971 DEC 21 2000en
dc.identifier.uriwww.nature.com
dc.identifier.urihttp://hdl.handle.net/1842/687
dc.description.abstractMeristem function in plants requires both the maintenance of stem cells and the specification of founder cells from which lateral organs arise. Lateral organs are patterned along proximodistal, dorsoventral and mediolateral axes (1,2). Here we show that the Arabidopsis mutant asymmetric leaves1 (as1) disrupts this process. AS1 encodes a myb domain protein, closely related to PHANTASTICA in Antirrhinum and ROUGH SHEATH2 in maize, both of which negatively regulate knotted-class homeobox genes. AS1 negatively regulates the homeobox genes KNAT1 and KNAT2 and is, in turn, negatively regulated by the meristematic homeobox gene SHOOT MERISTEMLESS. This genetic pathway defines a mechanism for differentiating between stem cells and organ founder cells within the shoot apical meristem and demonstrates that genes expressed in organ primordia interact with meristematic genes to regulate shoot morphogenesisen
dc.format.extent369139 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherNature Publishing Groupen
dc.subjectAsymmetricen
dc.subjectleavesen
dc.subjectmediatesen
dc.subjectleafen
dc.subjectpatterningen
dc.subjectstem cellen
dc.subjectfunctionen
dc.subjectArabidopsisen
dc.titleAsymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsisen
dc.typeArticleen


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