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dc.contributor.advisorHulme, Alison N.
dc.contributor.advisorLam, Hon Wai
dc.contributor.authorDonaldson, Lauren Rona
dc.date.accessioned2012-01-18T10:40:38Z
dc.date.available2012-01-18T10:40:38Z
dc.date.issued2009-06-29
dc.identifier.urihttp://hdl.handle.net/1842/5736
dc.description.abstractSmall molecule libraries have become essential for the development of drug discovery campaigns and chemical genetics. The studies towards the synthesis of a small molecule library, based upon the cis-ring fused phenanthridine core I, will be described. The first section of this thesis examines the development and application of a novel intramolecular Heck cyclisation to the synthesis of core phenanthridine structure II, via precursor III (Chapter 2).The second section (Chapter 3) describes the extension of this methodology towards the development of a library of phenanthridines IV. This includes methodology designed to incorporate the key principles of diversity-oriented synthesis, namely appendage, stereochemical and skeletal diversity. The final part of this thesis (Chapter 4) describes the merging of these various methodologies to generate a small library of novel phenanthridine analogues. Preliminary biological evaluation of the phenanthridine library using whole organism zebrafish phenotyping, will also be discussed.en
dc.language.isoenen
dc.publisherThe University of Edinburghen
dc.relation.hasversionDonaldson, L. R; Haigh, D.; Hulme, A. N. Tetrahedron 2008, 64, 4468-4477.en
dc.subjectsmall molecule libraryen
dc.subjectphenanthridineen
dc.subjectintramolecular Heck cyclisationen
dc.titleNew methods for the synthesis of biologically active phenanthridine-based librariesen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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