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dc.contributor.advisorWelburn, Sue
dc.contributor.advisorPicozzi, Kim
dc.contributor.advisorEisler, Mark
dc.contributor.authorSelby, Richard James
dc.date.accessioned2011-11-25T15:15:07Z
dc.date.available2011-11-25T15:15:07Z
dc.date.issued2011-07-05
dc.identifier.urihttp://hdl.handle.net/1842/5697
dc.description.abstractIn October 2006 an intervention was initiated to arrest the northerly advance through Uganda of the zoonotic parasite Trypanosoma brucei rhodesiense. This is a protozoal infection that is vectored by the tsetse fly. It is the aim of this thesis to review the impact of this large scale treatment programme in terms of animal health and human disease. The Stamp Out Sleeping Sickness (SOS) campaign was designed to target the cattle reservoir of T. b. rhodesiense in these newly affected areas by block treating >180,000 head of cattle. This was achieved in collaboration with final year vet students from the University of Makerere, Uganda. Farmers were also encouraged to spray their animals with deltamethrin in order to suppress the tsetse population. In order to monitor the impact of this intervention a base line survey was carried out. Evaluation of the logistics and implementation of the SOS campaign was assessed through interviews with personnel involved. Analysis by PCR revealed the prevalence of T. brucei s.l. as 15.57% (T. b. rhodesiense as 0.81%) within the cattle reservoir prior to SOS treatment. Follow up sampling was carried out at 23 locations at three, nine and 18 months. The prevalence of T. brucei s.l. was reduced post treatment, but in the absence of sustained vector control infections amongst the animals returned by nine months and subsequently exceeded the base line findings (P=<0.0001). It was observed that across most of the SOS area, T. b. rhodesiense did not re-establish following treatment. However, a significant cluster was identified where cases of both human and animal disease were continually reported. This cluster was noted to include the area immediately surrounding the Otuboi cattle market. This link between cattle movement and the spread of T. b. rhodesiense is an established one and is addressed by Ugandan governmental policy which states that ‘cattle traded at market must be treated with trypanocidal drugs prior to movement’. The findings presented here suggest that this policy may not be strictly enforced. The risk of spread is compounded at the northern districts of Uganda restock their domestic livestock following years of civil conflict. The majority of animals are traded in a northward direction – transporting infected animals from the endemic south. The scale of this trade is assessed through questionnaires, analysis of trade records and animal screening. Specific consideration is given to the implications of this cattle trade and impact this may have on the sustainability of the SOS campaign.en
dc.language.isoenen
dc.publisherThe University of Edinburghen
dc.relation.hasversionCARPENTER, S., MCARTHUR, C., SELBY, R., WARD, R., NOLAN, D. V., LUNTZ, A. J. M., DALLAS, J. F., TRIPET, F. & MELLOR, P. S. (2008) Experimental infection studies of UK Culicoides species midges with bluetongue virus serotypes 8 and 9. Veterinary Record 163, 589-592.en
dc.relation.hasversionSELBY, R. J. (2005) The ecology of UK culicoides and their potential as vectors of exotic diseases. Biological Life Sciences. Stoke on Trent, Keele.en
dc.subjectTrypanosoma bruceien
dc.subjecttsetse flyen
dc.subjectpublic healthen
dc.subjectSleeping Sicknessen
dc.subjectcattle movementen
dc.subjectinfection controlen
dc.titleLimiting the northerly advance of Trypanosoma brucei rhodesiense in post conflict Ugandaen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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