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dc.contributor.advisorVan Beek, Edwin
dc.contributor.advisorMacNee, William
dc.contributor.authorChoudhury, Gourab
dc.date.accessioned2018-11-01T11:34:02Z
dc.date.available2018-11-01T11:34:02Z
dc.date.issued2018-11-30
dc.identifier.urihttp://hdl.handle.net/1842/33186
dc.description.abstractA characteristic feature of Chronic Obstructive Pulmonary Disease (COPD) is an abnormal inflammatory response in the lungs to inhaled particles or gases. The ability to assess and monitor this response in the lungs of COPD patients is important for understanding the pathogenic mechanisms, but also provides a measure of the activity of the disease. Disease activity is more likely to relate to lung inflammation rather than the degree of airflow limitation as measured by the FEV1. Preliminary studies have shown the 18F fluorodeoxyglucose positron emission tomography (18F FDG-PET) signal, as a measure of lung inflammation, is quantifiable in the lungs and is increased in COPD patients compared to controls. However, the methodology requires standardisation and any further enhancement of the methodology would improve its application to assess inflammation in the lungs. I investigated various methods of assessing FDG uptake in the lungs and assessed the reproducibility of these methods, and particularly evaluated whether the data was reproducible or not in the COPD patients (smokers and ex-smokers). This data was then compared with a group of healthy controls to assess the role of dynamic 18F FDG-PET scanning as a surrogate marker of lung inflammation. My data showed a good reproducibility of all methods of assessing FDG lung uptake. However, using conventional Patlak analysis, the uptake was not statistically different between COPD and the control group. Encouraging results in favour of COPD patients were nonetheless shown using compartmental methods of assessing the FDG lung uptake, suggesting the need to correct for the effect of air and blood (tissue fraction effect) when assessing this in a highly vascular organ like the lungs. A prospective study analysis involving a bigger cohort of COPD patients would be desirable to investigate this further.en
dc.contributor.sponsorMedical Research Council (MRC)en
dc.language.isoenen
dc.publisherThe University of Edinburghen
dc.relation.hasversionQuantification of Lung PET Images: Challenges and Opportunities. Delphine L Chen, Joseph Cheriyan, Edwin Chilvers, Gourab Choudhury, et al. Jan 2017 Journal of Nuclear Medicine. DOI 10.2967/jnumed.116.184796en
dc.relation.hasversionRole of Inflammation and Oxidative Stress in the Pathology of Ageing in COPD: Potential Therapeutic Interventions. G Choudhury and W MacNee. Sep 2016. COPD Journal of Chronic Obstructive Pulmonary Disease. COPD Journal of Chronic Obstructive Pulmonary Disease 14(1):1-14en
dc.relation.hasversion18F-fluorodeoxyglucose (18FDG) PET pulmonary imaging in COPD. G Choudhury, M Connell, A Fletcher, E Van Beek, W MacNee. September 2015. European Respiratory Journal 46(suppl 59):OA4988. DOI 10.1183/13993003.congress- 2015.OA4988en
dc.relation.hasversion18F-Fluorodeoxyglucose (18FDG) PET pulmonary imaging: Role in detecting vascular inflammation. Janice Wong, A Vasey, S Ferguson, G Choudhury. September 2015. European Respiratory Journal 46(suppl 59):OA4989. DOI 10.1183/13993003.congress-2015.OA4989en
dc.relation.hasversion18F-fluorodeoxyglucose (18FDG) Pet Pulmonary Imaging: Comparative Methodology in COPD Patients. Gourab Choudhury, A Fletcher, M Connell, W MacNee. December 2014. Thorax 69(Suppl 2):A13-A13en
dc.relation.hasversionDynamic PET pulmonary imaging in COPD patients, comparing various modalities. G Choudhury, M Connell, A Fletcher, E Van Beek, W. MacNee. ERS 2014en
dc.relation.hasversion18F-fluorodeoxyglucose (18F-FDG) PET/CT assessment of aortic inflammation and calcification in COPD. Susan Fernandes, G Choudhury et al. DOI. 10.1183/1393003.congress- 2017.PA785.en
dc.relation.hasversion18F-Fluorodeoxyglucose (18FDG) PET pulmonary imaging: Methodology: Is there a relationship with lung density? G Choudhury, M Connell, A Fletcher, S Ferguson, W MacNee; Scottish Thoracic Society Meeting April 2016.en
dc.subjectChronic Obstructive Pulmonary Diseaseen
dc.subjectCOPDen
dc.subjectpositron emission tomographyen
dc.subjectPETen
dc.subjectcomputerized tomographyen
dc.subjectCT scansen
dc.subjectlung inflammationen
dc.titleRole of 18F FDG PET/CT as a novel non-invasive biomarker of inflammation in chronic obstructive pulmonary diseaseen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnameMD Doctor of Medicineen


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