1. The treatment of Addison's Disease is traced
from its inception to the present time and the
principles underlying the various forms of
modern therapy are propounded and discussed.
2. All cases of Addison's Disease that have entered
hospitals in the Edinburgh area in the period
1927 - 1938 are reviewed and their treatment
3. Original investigations into the different forms
of modern therapy have been carried out and
the results are presented.
4. It is shown that cortical extract is undoubtedly
beneficial when administered by itself and
that its use is essential in times of "crisis".
5. The effect of Cortical extract is greatly enhanced by the coincident use of sodium chloride
or abundant salines.
6. Evidence is produced to show that between the
crises the administration of cortical extract
is not necessary, provided that a high sodium
chloride and a low potassium intake are maintained, and that no intercurrent toxic condition
7. It is demonstrated that a high potassium intake
in Addison's Disease is detrimental, but tais
may be "covered" if ample cortical extract is
given or if the sodium intake is sufficiently
8. It is suggested that all cases of Addison's
Disease should have a diet with a low potassium
content, and the difficulties underlying the
preparation of such a diet are discussed.
9. Several typical food:- stuffs are tabulated according to their potassium content and a suggested low potassium diet is outlined.
10. Cases of Addison's Disease are described illustrating the application of the above conclusions.