1. Outline of the nature of the published papers:
The papers presented in the field of chemotherapy fall
into two groups:
(a) Papers on antimalarials;
(b) Papers on antibiotic peptides and amino acids.
In addition, the candidate presents, along with and as part of this thesis,
his book, "The Basis of Chemotherapy", as an original contribution to the
theoretical development of the subject.
2. List of papers published on chemotherapy:
|| 1. King, H. and Work, T.;-. Antiplasmodial action and chemical constitution.
Part III. Carbinolamines derived from naphthalene and quinoline.
J.chem.Soc., 1940, p.1307.
|| 2. Work T.S. intiplasmodial action and chemical constitution. Part IV.
The synthesis of some complex carbinolamines and polyamines.
J.chem.Soc., 1940, p.1315.
|| 3. King, H. and Work T.S. Antiplasmodial action and chemical constituion.
Part V. Carbinolamines derived from 6- methoxyquinoline.
J.chem.Soc., 1942, p.401.
|| 4. Wore. T.S. Antiplasmodial action and chemical constitution. Part VI.
Compounds related to lepidylamine. J.chem.Soc., 19112, p.426.
|| 5. Work. T.S. The synthesis of amines from amides through amidodichlorid.es.
J.chem.Soc., 1942, p.429.
|| 6. Work, T.S. Antiplasmodial action and chemical constitution. Part VII.
Derivatives of quinine and isoquinine. J. chem.Soc. , 1944 p. 334.
|| 7. Work, T.S. The synthesis of antimalarial compounds related to niquidine.
Part I. Model experiments on the synthesis of r+.uinolyl carbinols.
J. them. Soc. , 1946, p.194.
|| 8. Work, T.S. The synthesis of antimalarial compounds related to niquidine.
Part II. Synthesis of a dihydro -x- niquidine. J. them. Toc. , 1946
p,197.
|| 9. Work, T.S. The synthesis of antimalarial compounds related to niquidine.
Part III. Alternative synthesis of dihydro -x- niquidine. J.chem.
Soc., 1947, p.222.
|| 10. Tonkin, I.M. and Work, T.S. A new antimalarial drug. Nature, 1945,
156, 630.
|| 11. Work, T.S. d- and 1- amino acids in antibiotics. Biochem.Soc.Symposia,
194.8, No. 1, p.61.
|| 12. Harris, J.I. and Work, T.S. Synthetic pentapeptides related to gramicidin -S.
Nature, 1948, 161, 804.
|| 13. Harris, J.I. and Work, T.S. Lysine analogues as inhibitors of bacterial
growth. Biochem.J., 1950, 46, 190.
|| 14- Harris, J.I. and Work, T.S.
The synthesis of peptides related to gramicidin-S and the
antibiotic peptides. I. Tri-peptides. Biochem.J., 1950, 46, 196.
|| 15. Harris, J.I. and Work, T.S.
The synthesis of peptides related to gramicidin-S and the significance of optical configuration in
antibiotic peptides. II. Penta-peptides. Biochem.J., 1950, 46, 582.
|| 16. Jerk, T.S. A discussion on antibiotic acitivity of growth factor analogues.
Proc.Roy.Soc. , B, 1949, 136, 159.
|| 17. Work, T.S. and Work, P. The Basis of Chemotherapy. Oliver & Boyd,
Edinburgh, 1948, xx, 4.35 p.
3. Other original work presented. with this thesis:
Since 1936, when the candidate was awarded the degree of
Ph.D.) he has worked also in the field of natural product chemistry and has
published original work on vitamin E, Cannabis indica resin, analogues of
acetyl choline, the toxic factors in bleached wheat flour, and on local anaesthetics.
4. List of papers relating to 3:
|| 18. Todd, A.R., Bergel, F., Taldmann, H. and 'ork, T.S. Constituents of
vitamin E concentrates from rice- and wheat -germ oils. Nature,
1937, 1,,D, 361.
|| 19. Todd, A.R., Bergel, F., ';Taldmann, H. and '': fork, T.S. Studies on vitamin
E. I. The isolation of some crystalline alcohols from the unsaponifiable matter of rice -and wheat -germ oils. Biochem.J. ,' 1937, 31, 2247.
|| 20. Todd, A.R., Bergel, F. and Work, T.S. Studies on vitamin II. The
isolation of ß- tocopherol from wheat -germ oil. Biochem.J.,
1937, 31, 2257.
|| 21. Bergel, F. , Jacob, A., ,Todd, A.R., and 'Work, T.S. Vitamin E Structure
of 3- tocopherol. Nature, 1938, 14..1, 646.
|| 22. Bergel, F. , Todd, A.R. and ''Fork, T.S. Studies on vitamin E. Part III.
Observations on the structure of a- and 3- tocopherol. J.chem.
Soc., 1938, p.253.
|| 23. Bergel, F., Jacob, A. , Todd, A.R. and work, T.S. Vitamin E synthesis of
a- tocopherol. Nature, 1938, 11.2, 36.
|| 24. Bergel, P. , Jacob, A., Todd, A.R. and 'Work, T.S. Studies on vitamin E.
Part IV. Synthetic experiments in the couroaran and chroman series.
The structure of the tocopherols. J. chem.Soc. , 1938, p. 1375.
|| 25. Bergel, F., Copping, 'i.l; . , Jacob, A., Todd., A.R. and Bork, T.S. Studies
on vitamin Part V. Synthesis of racemic a- tocopherol and of a lower homologue. J. chem. S oc. , 1938, p.1382.
|| 26. Jacob, , Steiger, M., Todd, A.R. and 'pork, T.S. Studies on vitamin
E. Part DTI. Synthesis of lower homologues of u- tocopherol.
J.chem.Soc., 1939, p.542.
|| 27. Work, T.S., Bergel, F. and Todd, A.A. The active principles of Cannabis
ind.ica resin. I. Biochem.J. , 1939, 33, 123.
|| 28. dark, T.S. The synthesis of N- trimethylglycycholine. J . chem. Soc. , 1941,
p.190.
|| 29. Macintosh, F.C. and 7ork, T.S. Some aminoethanol derivatives possessing
local anaesthetic acitivty. Quart.J.Fharmacy, 1914, lZ., 16.
|| 30. Work, T.S. The biochemical effects of mutation. Ann.Rep.Chemical Society,
1947, p.254-
|| 31. Campbell, P.N., Work, T.S. and Hellanby, Sir E. Isolation of a crystalline
toxic factor from agenized -;heat flour. Rature, 1950, 165,
345.
|| 32. Campbell, P.L. , ffork, T.S. and Mellanby, Sir S. The isolation of a toxic
substance from agenized wheat flour. Biochem, J., 1951, 48, 106.
