Within recent years Organotherapy has made
greater advances than perhaps any other branch of
Myxoedema and Cretinism have been definitely proved
to be caused by a deficiency or total absence of
thyroid gland secretion and an extract of this gland
is now the specific treatment for these diseases.
Experimental work on adrenalin, an extract of the
suprarenal gland, soon proved it to be one of the most
powerful styptic drugs we possess. Adrenalin acts by
causing local vaso- constriction and powerfully raises
the blood pressure, hence it is largely used in the
treatment of shock. The active principle of adrenalin
has been isolated and a synthetic preparation produced
which answers to the tests of the natural extract.
Whilst Resident Medical Officer at Queen
Charlotte's I was constantly having inquiries from
practitioners as to the action of pituitrin in midwifery,
thus proving how interested they were in this
drug. One question was invariably asked, namely,
was it always safe to use pituitrin in suitable cases?
I may say I have used pituitrin in upward of sixty
cases and its action has never given me the least
cause for anxiety, nor have I ever seen it cause a rash, as described by some writers.
In all my cases I found that pituitrin had a
definite action on the uterus, causing increased con - iractions, a rapid rise in blood pressure, maintained
for from twelve to twenty -four hours, and that there
was a marked slowing of the pulse rate.