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dc.contributor.authorCleaveland S.en
dc.contributor.authorHampson K.en
dc.contributor.authorDushoff J.en
dc.contributor.authorHaydon D.T.en
dc.contributor.authorKaare M.en
dc.contributor.authorPacker C.en
dc.contributor.authorDobson A.en
dc.date.accessioned2009-09-07T14:32:39Z
dc.date.available2009-09-07T14:32:39Z
dc.date.issued2009-03-01en
dc.identifier.citationCleaveland S., Hampson K., Dushoff J., Haydon D.T.. (2009-03-01) Transmission Dynamics and Prospects for the Elimination of Canine Rabies, PLOS Biology 7(3) 462-471en
dc.identifier.issn1544-9173en
dc.identifier.urihttp://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000053en
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pbio.1000053en
dc.identifier.urihttp://hdl.handle.net/1842/3031
dc.description.abstractRabies has been eliminated from domestic dog populations in Western Europe and North America, but continues to kill many thousands of people throughout Africa and Asia every year. A quantitative understanding of transmission dynamics in domestic dog populations provides critical information to assess whether global elimination of canine rabies is possible. We report extensive observations of individual rabid animals in Tanzania and generate a uniquely detailed analysis of transmission biology, which explains important epidemiological features, including the level of variation in epidemic trajectories. We found that the basic reproductive number for rabies, R-0, is very low in our study area in rural Africa (similar to 1.2) and throughout its historic global range (<2). This finding provides strong support for the feasibility of controlling endemic canine rabies by vaccination, even near wildlife areas with large wild carnivore populations. However, we show that rapid turnover of domestic dog populations has been a major obstacle to successful control in developing countries, thus regular pulse vaccinations will be required to maintain population-level immunity between campaigns. Nonetheless our analyses suggest that with sustained, international commitment, global elimination of rabies from domestic dog populations, the most dangerous vector to humans, is a realistic goal.en
dc.format.extent465118 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectparenteral vaccination campaign; acute respiratory syndrome; basic reproductive ratio; dog rabies; machakos district; bite injuries; rural africa; disease; population; epidemicen
dc.titleTransmission Dynamics and Prospects for the Elimination of Canine Rabiesen
dc.typeArticleen


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