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dc.contributor.authorAdler, Jeremyen
dc.date.accessioned2018-05-14T10:12:49Z
dc.date.available2018-05-14T10:12:49Z
dc.date.issued1983en
dc.identifier.urihttp://hdl.handle.net/1842/29759
dc.description.abstracten
dc.description.abstractThe inactin anaesthetized rat shews cardiovascular reflex responses. Heat rate is under sympathetic but not vagal control.en
dc.description.abstractClonidine reduces the heart rate and blood pressure in the inactin anaesthetized rat. The reduction in heart rate involves reducing sympathetic cradiac drive. The fall in blood pressure includes a reduction in peripheral resistance.en
dc.description.abstractUsing a newly developed "delayed" hindlimb perfusion the reduction in peripheral resistance was seen to be neurally mediated. A peripheral vasodilator action was not seen with clonidine.en
dc.description.abstractClonidine was administered by four different routes which were expected to provide access to selected areas in the brain. Intravenous, intracarotid artery, intraventricular and intravertebral artery. Administration into the ventricular system of the brain was slighty more potent in reducing arterial pressure than intravenous injection. Intracarotid and intravenous were equipotent. Intravertbral was by far the most effective, requiring 5% of the intravenous dose to cause an equivalent cardiovascular response.en
dc.description.abstractAutoradiography with H-clonidine was used to locate the injected clonidine. The new CEA Verken tritium sensitive film was used and proved able to detect very low levels of tritium. Each route of administration resulted in a different pattern of distribution.en
dc.description.abstractClonidine administered intravenously distributed evenly throughout the CN3.en
dc.description.abstractIntacarotid administration selectively reached rostral areas. Intraventricular administration had the spread limited to periventicular areas.en
dc.description.abstractIntravertebral clonidine reached the medulla, pons, areas of the cerebellum and upper areas of the spinal cord.en
dc.description.abstractComparison with the different hypotensive affects led to the conclusion that the site of action was within the medulla but not in the periventricular areas.en
dc.publisherThe University of Edinburghen
dc.relation.isreferencedbyAlready catalogueden
dc.subjectAnnexe Thesis Digitisation Project 2018 Block 18en
dc.titleThe mechanism and site of action of clonidine in the raten
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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