The term Acetonaemia is used in this thesis
to denote those changes in the blood and urine
which occur in the condition of Acid Intoxication,
as well as the clinical manifestations. These
changes are brought about by the presence of
acetone bodies, viz: aceto-acetic acid,
B-oxybutyric acid and Acetone. for this purpose
the term "acidosis" may be defined as a reduction
of the plasma bicarbonate. Such reduction may or
may not be due to, or associated with, an excess
of ketone bodies in the blood; that is to say, a
condition of acidosis may be prevent and frequently
.is, without acetonaernia etc. As a matter of fact
it has long been known that ketosis may occur in
the presence of an alkalosis.
Ketosis is, of course, more commonly met with
in children than in adults, because, in the former,
owing to their comparatively poorly developed
cerebral inhibition, with consequent lack of
emotional control, greater and more frequent calls
are made on the glycogen stores Of the liver. It
is for this reason too, I think,that the symptoms
described in this article are more marked in nervous
children, but they are certainly not confined to
them. The one biochemical finding which is
present in all these children is a lowered plasma
bicarbonate, though the diminution may only be
slight. Until our knowledge of the subject of the
condition more complete, the term ''the acid child"
would be correct and convenient, and would best
describe the patient.
The development of this subject has been very
gradual, although it has occupied a prominent place
in the field of medicine for several decades.
Numerous erroneous conceptions have arisen from
time to time, acid these are being eliminated only
v4ith difficulty. In recent year there has been
renewed activity in the study of acidosis,
particularly in tho e types of non -diabetic origin.