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dc.contributor.authorMcCafferty, Johnen
dc.date.accessioned2018-03-29T12:18:43Z
dc.date.available2018-03-29T12:18:43Z
dc.date.issued2006en
dc.identifier.urihttp://hdl.handle.net/1842/29259
dc.description.abstracten
dc.description.abstractIt was hypothesized that Respiratory heat and moisture loss (RHML) would be altered in patients with Asthma and Chronic obstructive pulmonary disease (COPD) due to the effects of airway inflammation and re-modeling. By creating a novel device incorporating humidity, temperature and flow sensors, RHML was measured in 25 normal controls, 33 asthmatics and 17 patients with COPD. In normal subjects RHML was found to be dependent on breathing pattern as defined by tidal volume and minute ventilation whereas no association was found between RHML and body surface area or forced expiratory volume in one second (FEV1). At matched breathing patterns asthmatics whether in exacerbation or stable showed a small but significant increase in RHML compared to controls (exacerbation asthmatics -93.2 ± 0.8 (SD), p=0.003, stable asthma - 89.3 ± 7.4, p=0.025 and controls 85 ± 4.3 Joules/L). No significant difference was found in RHML between the asthmatics with an exacerbation and those with stable disease. COPD patients showed no significant difference in RHML (stable group- 83 ± 4.8, p=0.23 and exacerbation group - 81 ± 5.8 Joules/L, p=0.06) compared to controls or between exacerbation and stable groups. Evaporative heat loss was the major heat transfer modality (up to 3-times the dry convective heat loss). It can be concluded that asthma is associated with a measurable increase in heat and moisture loss in breath and that this may reflect the inflammatory and vascular changes known to occur in the asthmatic airway. Further longitudinal studies are required to assess whether the technique developed in this study can provide a practical means to measure inflammation in asthma.en
dc.publisherThe University of Edinburghen
dc.relation.isreferencedbyAlready catalogueden
dc.subjectAnnexe Thesis Digitisation Project 2018 Block 17en
dc.titleRespiratory heat and moisture loss in health, asthma and chronic obstructive pulmonary disease (COPD)en
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnameMD Doctor of Medicineen


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