1. Allopregnane- 3a,20a -diol has been isolated from
the urine of human patients, who were shown to have
no detectable amount of endogenous allopregnane3a, 20a -diol, after intramuscular administration of
2. The amount of allopregnane- 3a,20a -diol accounted
for about 0.3; of the administered progesterone.
3. The ratio (30:1) of pregnane- 3a,20a -diol: allopregnane -3a,20ä -diol arising from administered progesterone is not significantly different from that
found in human late pregnancy urine.
4. It is suggested that most, if not all, of the
allo -pregnanti- 3a,20ä -diol present in human late
pregnancy urine arises from progesterone.