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Please use this identifier to cite or link to this item: http://hdl.handle.net/1842/2088

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Title: Virulence evolution in response to vaccination: the case of malaria
Authors: Mackinnon, Margaret J
Gandon, Sylvain
Read, Andrew F
Issue Date: 2007
Abstract: One theory of why some pathogens are virulent (i.e. they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and resource extraction can damage the host. Here we describe our studies in malaria that test this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered.
Description: Invited paper for the journal Vaccine summarising a workshop at Rutgers University in July 2005 on Vaccination and its evolutionary consequences
Keywords: biological sciences
immunology
URI: http://hdl.handle.net/1842/2088
Appears in Collections:Biological Sciences publications

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