Information Services banner Edinburgh Research Archive The University of Edinburgh crest

Edinburgh Research Archive >
Biological Sciences, School of >
Biological Sciences publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1842/2086

This item has been viewed 5 times in the last year. View Statistics

Files in This Item:

File Description SizeFormat
PRSB 274.pdf158.25 kBAdobe PDFView/Open
Title: Evolution of parasite virulence when host responses cause disease
Authors: Day, Troy
Graham, Andrea
Read, Andrew F
Issue Date: Aug-2007
Citation: Proc. R. Soc. B (2007) 274, 2685–2692
Publisher: The Royal Society
Abstract: The trade-off hypothesis of virulence evolution rests on the assumption that infection-induced mortality is a consequence of host exploitation by parasites. This hypothesis lies at the heart of many empirical and theoretical studies of virulence evolution, despite growing evidence that infection-induced mortality is very often a by-product of host immune responses. We extend the theoretical framework of the trade-off hypothesis to incorporate such immunopathology and explore how this detrimental aspect of host defence mechanisms affects the evolution of pathogen exploitation and hence infection-induced mortality. We argue that there are qualitatively different ways in which immunopathology can arise and suggest ways in which empirical studies can tease apart these effects. We show that immunopathology can cause infection- induced mortality to increase or decrease as a result of pathogen evolution, depending on how it covaries with pathogen exploitation strategies and with parasite killing by hosts. Immunopathology is thus an important determinant of whether public and animal health programmes will drive evolution in a clinically beneficial or detrimental direction. Immunopathology complicates our understanding of disease evolution, but can nevertheless be readily accounted for within the framework of the trade-off hypothesis.
Description: This article is (c) 2007 The Royal Society
Keywords: immunopathology
ecological immunology
pathogenicity
biological sciences
URI: http://dx.doi.org/10.1098/rspb.2007.0809
http://hdl.handle.net/1842/2086
Appears in Collections:Biological Sciences publications

Items in ERA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! Unless explicitly stated otherwise, all material is copyright © The University of Edinburgh 2013, and/or the original authors. Privacy and Cookies Policy