Information Services banner Edinburgh Research Archive The University of Edinburgh crest

Edinburgh Research Archive >
Molecular, Genetic and Population Health Sciences, School of >
Molecular, Genetic and Population Health Sciences thesis and dissertation collection >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1842/2016

This item has been viewed 21 times in the last year. View Statistics

Files in This Item:

File Description SizeFormat
Baig2007.rtf38.73 MBRTFView/Open
Title: Polymorphisms in the COMT and MAOA genes and their consequences for Clinical, Neuropsychological and Neuroimaging dimensions in a population at High Risk of Schizophrenia
Authors: Baig, Benjamin Jacob
Supervisor(s): Johnstone, Eve Cordelia
Issue Date: Jun-2007
Abstract: Schizophrenia is a severe an enduring psychiatric condition occurring in around 1% of the general population. In addition to clinical symptoms, sufferers show neuropsychological deficits. Neuroimaging changes including deficits in frontal and temporal lobe structures can be seen in subjects with the condition. Of the many aetiological perspectives of Schizophrenia the heritability of the illness and the role of excess of the neurotransmitter dopamine are important. Dopamine is degraded by two enzymes COMT and MAOA. Thus mutations in the genes controlling the effectiveness of these enzymes may render subjects with a hyperdopaminergic state. This thesis will concentrate on two specific Single Nucleotide Polymorphisms in the MAOA and COMT genes and their consequences on the clinical, neuropsychological and neuroimaging phenotype. The study population for this thesis will be taken from the Edinburgh High Risk Study. This is a prospective cohort of individuals at high risk of schizophrenia due to having two or more relatives with the condition. It is in this population that the effects of the genes may be studied without the contaminating effects of psychotropic medication or other illness factors. The results from this thesis show that COMT genotype can be related to structural and functional neuroimaging changes. Additionally MAOA genotype appears to have a significant effect on affective symptoms and neuropsychological traits. These findings suggest a mechanism for how a hyperdopaminergic state may impact on the Schizophrenia Phenotype.
Sponsor(s): University of Edinburgh
Keywords: Molecular and Clinical Medicine
schizophrenia
Neuroimaging
Neuropsychology
URI: http://hdl.handle.net/1842/2016
Appears in Collections:Molecular, Genetic and Population Health Sciences thesis and dissertation collection

Items in ERA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! Unless explicitly stated otherwise, all material is copyright © The University of Edinburgh 2013, and/or the original authors. Privacy and Cookies Policy