Now showing items 1-20 of 7415

  • Contribution of Lsh to DNA methylation during neurodevelopment 

    Duthie, Leanne Beth (The University of Edinburgh, 2019-11-25)
    DNA methylation is considered one of the oldest epigenetic modifications and is associated with repression of transcriptional activity. Embryonic development sees dynamic changes in this mark. Initially, widespread ...
  • A computational approach to magnocellular oxytocin neuron dynamics 

    Maicas Royo, Jorge (The University of Edinburgh, 2019-11-25)
    Magnocellular oxytocin neurones, found mainly in the supraoptic nucleus and in the paraventricular nucleus of the hypothalamus, project their axons to the posterior pituitary, from where they secrete oxytocin into the ...
  • Six cases 

    Wilson, Arthur James (The University of Edinburgh, 1921)
    Six cases: written for the Wightman Prize in Clinical Medicine, 1921 • I. A case of penile hypospadias; II. A case of diabetes insipidus; III. A case of carcinoma pylori; IV & V. 2 cases of diabetes mellitus; VI. A case ...
  • Seasonal influenza vaccine effectiveness in asthma 

    Vasileiou, Eleftheria (The University of Edinburgh, 2019-07-06)
    Introduction Influenza is a seasonal viral respiratory infection that causes considerable morbidity and mortality, particularly in individuals with chronic medical conditions such as asthma. Vaccination is one of the most ...
  • Transcriptional and functional consequences of neuron-astrocyte interactions 

    Jiwaji, Zoeb (The University of Edinburgh, 2019-06-29)
    Astrocytes play a large number of roles essential for CNS health and are important mediators in CNS disease, demonstrating both neuroprotective and neurotoxic phenotypes. Non-cell autonomous interactions between neurons and ...
  • Impact of genetic and environmental risk factors for schizophrenia on cortical brain structure 

    Neilson, Emma (The University of Edinburgh, 2019-07-06)
    It is now accepted that Schizophrenia, a neurodevelopmental disorder which affects around 1% of the population, is influenced by both genetic and environmental risk factors. Schizophrenia is evidenced as being heritable ...
  • Breast cancer heterogeneity within the neoadjuvant window 

    Pearce, Dominic (The University of Edinburgh, 2019-07-06)
    Breast cancer affects ~55,000 women in the UK annually. Key to the reliable management of the disease is robust characterisation of an individual’s tumour, to best determine the most appropriate treatment and likely ...
  • Anxiety after stroke: intervention design and a randomised controlled trial 

    Chun, Ho-Yan Yvonne (The University of Edinburgh, 2019-07-06)
    INTRODUCTION: Anxiety is common and potentially debilitating after stroke. There is no reliable evidence to guide treatment. Barriers exist in accessing psychological care after stroke. Little is known about anxiety ...
  • Interaction of host and viral microRNAs with infectious laryngotracheitis virus transcripts 

    Ferguson, Jack (The University of Edinburgh, 2019-06-29)
    Infectious Laryngotracheitis Virus (ILTV) is an Alphaherpesvirus of the domesticated chicken and other economically important fowl such as pheasants, peafowl and turkeys. It causes an upper respiratory disease that is ...
  • Experimental approaches to studying human testicular development 

    Hutka, Marsida (The University of Edinburgh, 2019-07-06)
    Survivors of childhood cancer encounter a broad spectrum of long-term side effects, including infertility after completion of cancer therapy. Prepubertal boys do not yet produce sperm; therefore they cannot benefit from ...
  • Role of prolyl hyrdoxylase domain enzymes in normal and malignant haematopoiesis 

    Lawson, Hannah (The University of Edinburgh, 2019-07-06)
    Acute Myeloid Leukaemia (AML) arises from a dysregulation in haematopoietic stem and progenitor cells (HSPCs), leading to the production of highly proliferative blast cells. Current chemotherapies can eliminate these ...
  • Strategies for earlier diagnosis of endometrial cancer: targeting endometrial hyperplasia 

    Sanderson, Peter Andrew (The University of Edinburgh, 2019-07-06)
    Endometrial cancer (EC) is the most common gynaecological malignancy in the developed world, with approximately 9000 new cases reported annually within the UK (2013-2015). Incidence rates of EC have been steadily climbing ...
  • Factors influencing cold ischaemia time in deceased donor kidney transplants 

    Shrestha, Sussie (The University of Edinburgh, 2019-07-06)
    Kidney transplant remains the optimal treatment for majority of patients with end stage renal failure. The major challenge facing the transplant community is the shortage of organs for donation as demand outstrips supply. ...
  • Regulation of neutrophilic inflammation by hypoxic signalling pathways 

    Watts, Emily Rose (The University of Edinburgh, 2019-07-06)
    Neutrophils are essential for effective innate immunity. Conversely, inappropriate or excessive neutrophil activation can result in damaging inflammation. This damage is implicated in the pathogenesis of a number ...
  • Uncovering novel regulators of neural fate commitment in embryonic stem cells 

    Rao, Chandrika (The University of Edinburgh, 2019-07-06)
    How do pluripotent stem cells reliably select the neural lineage during differentiation? When embryonic stem (ES) cells are exposed to a homogeneous signalling environment, differentiation remains variable and unpredictable. ...
  • Cardiac magnetic resonance imaging assessment of aortic stenosis to improve clinical care 

    Everett, Russell James (The University of Edinburgh, 2019-07-06)
    Background Aortic stenosis is the commonest valve disease requiring intervention in the developed world. Current guideline-based management strategies are based on historical observational data or expert opinion and may ...
  • Mechanisms of actions and roles of 5α-reduced glucocorticoids during inflammation and wound repair 

    Abernethie, Amber Jean (The University of Edinburgh, 2019-07-06)
    Topical inflammatory diseases are most commonly treated with glucocorticoids, such as hydrocortisone, which have debilitating side effects including a range of systemic metabolic side effects as well as local effects ...
  • Developing an object-based colocalisation analysis method to measure synaptic diversity 

    Anton, Vlad (The University of Edinburgh, 2019-07-06)
    Protein colocalisation is of particular importance in the study of protein function. To address the inadequacies of previous colocalisation analysis methods, the novel Vicinity-based Localisation Adjacency Determination ...
  • Neural basis of genetic vulnerability to bipolar disorder 

    Sussmann, Jessika Elizabeth Debora (The University of Edinburgh, 2019-07-06)
    Abnormalities of reward processing, decision-making and emotion processing are core features of bipolar I disorder (BD). These processes are closely linked with fronto-striatal and midbrain circuitry. I sought to test ...
  • Analysis, interpretation, and visualisation of DamID-seq experiments 

    Ashmore, James (The University of Edinburgh, 2019-07-06)
    DNA adenine methyltransferase identification with sequencing (abbreviated DamIDseq) is a technique that can measure protein-DNA interactions in the genome. Unlike chromatin immunoprecipitation with sequencing (abbreviated ...