Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Obesity and metformin in pregnancy
(The University of Edinburgh, 2017-07-08)Obesity is the most common antenatal comorbidity, affecting one in five of the antenatal population in the UK. It is associated with adverse outcomes for mother and baby in both the short and long term. Increasing data ... -
Understanding the role of UBA1 in the pathogenesis of spinal muscular atrophy
(The University of Edinburgh, 2018-07-10)Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by widespread loss of lower motor neurons from the spinal cord. Lower motor neuron degeneration leads to a progressive decline ... -
Role of mast cells in women's health and disorders of the endometrium
(The University of Edinburgh, 2017-07-08)During the normal menstrual cycle, the human endometrium undergoes extensive tissue remodelling under the influence of ovarian-derived hormones. The endometrium has well defined stromal and epithelial compartments with ... -
Imaging calcification in aortic stenosis
(The University of Edinburgh, 2018-06-30)BACKGROUND Aortic stenosis is a common and potentially fatal condition in which fibro-calcific changes within the valve leaflets lead to the obstruction of blood flow. Severe symptomatic stenosis is an indication for ... -
Using single-cell RNA sequencing to investigate mesenchymal cells during renal injury
(The University of Edinburgh, 2017-12-01)Renal fibrosis comprises extra cellular matrix (ECM) deposition, distortion of normal tissue architecture, and ultimately progressive renal impairment, and is the shared end-point of many diverse types of renal injury. ... -
Tumour evolution over time, treatment and progression; exploring the molecular heterogeneity of oestrogen receptor positive breast cancer
(The University of Edinburgh, 2017-12-01)Introduction Recent advances in microarray technology have allowed more understanding of the complex molecular biology of breast cancer. The traditional prognostic information afforded by hormone receptor status and ... -
Role of Chlamydia trachomatis infection in adverse pregnancy outcomes
(The University of Edinburgh, 2017-07-08)Chlamydia trachomatis (Ct), the most common sexually transmitted bacterium, has been associated with adverse pregnancy outcomes including controversial data on miscarriage, intrauterine growth restriction and low birth ... -
Regulatory role of Pax6 on cell division cycle associated 7 and cortical progenitor cell proliferation
(The University of Edinburgh, 2017-07-07)Forebrain development is controlled by a set of transcription factors which are expressed in dynamic spatiotemporal patterns in the embryonic forebrain and are known to regulate complex gene networks. Pax6 is a transcription ... -
Origins and heterogeneity of adipose tissue: investigating the role of the Wilms’ tumour 1 (Wt1) gene
(The University of Edinburgh, 2018-06-30)Largely as a consequence of the ongoing obesity epidemic, research into adipose tissue biology has increased substantially in recent years. Worldwide, the number of people classed as overweight or obese is growing, and ... -
Experiences of patients living and dying with advanced heart failure in Kenya: a qualitative serial interview study
(The University of Edinburgh, 2017-12-01)Background The number of people in Sub-Saharan Africa dying of heart failure is increasing. However, little is known about their experiences and needs. In Kenya, palliative care services are available for some people ... -
Effect of statin treatment on preterm labour
(The University of Edinburgh, 2017-12-01)Preterm labour (PTL) is defined as labour before 37 completed weeks of gestation. Despite advances in medical research, PTL remains a major clinical problem. Preterm birth (PTB) rates range from approximately 5-18% ... -
Effect of preterm birth on white matter tracts and infant cognition
(The University of Edinburgh, 2018-06-30)Preterm birth (defined as birth before 37 weeks) is a leading cause of neurocognitive impairment in childhood, including difficulties in social cognition and executive function. Microstructural divergence from typical ... -
Epigenetics of paediatric Crohn's disease
(The University of Edinburgh, 2017-07-08)Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a complex disease with multiple aetiological factors including genetics, environmental exposures and microbiota. Epigenetic ... -
Effect of antenatal glucocorticoid treatment on fetal heart maturation in mice
(The University of Edinburgh, 2018-06-30)Glucocorticoids - cortisol and corticosterone - are steroid hormones synthesised in the adrenal gland that are important mediators of the stress response. Glucocorticoids are also vital in development to aid in organ ... -
Development and testing of a behavioural change intervention to increase physical activity, predominantly through walking, after stroke
(The University of Edinburgh, 2018-06-30)Introduction Globally stroke remains the leading cause of adult disability. An aging population and a reduction in stroke case fatality has led to an increasing number of people living with stroke i.e. stroke survivors. ... -
Practical use of the multiple breath washout test in children: biological variability in health and disease
(The University of Edinburgh, 2017-12-01)The Multiple Breath Washout (MBW) test is increasingly being recognised as a sensitive method of detecting early small airways lung disease. Indices of MBW include lung clearance index (LCI), Scond and Sacin. Factors ... -
CX3CR1/CX3CL1 axis drives the migration and maturation of oligodendroglia in the central nervous system
(The University of Edinburgh, 2017-12-01)In the central nervous system, the axons of neurons are protected from damage and aided in electrical conductivity by the myelin sheath, a complex of proteins and lipids formed by oligodendrocytes. Loss or damage to the ... -
Targeting aerobic glycolysis in breast and ovarian cancer
(The University of Edinburgh, 2017-07-08)Cancer cells, unlike normal tissue, frequently rely on glycolysis for the production of energy and the metabolic intermediates required for their growth regardless of cellular oxygenation levels. This metabolic ... -
TET mediated 5’hydroxymethylation in the pathogenesis of non alcoholic fatty liver disease
(The University of Edinburgh, 2017-07-08)Non-alcoholic fatty liver disease (NAFLD) now affects around one in four adults in the human population and parallels the global increase in obesity. Within the spectrum of NAFLD, simple steatosis is associated with ... -
Spectroscopically bioorthogonal Raman imaging approaches for intracellular visualisation
(The University of Edinburgh, 2017-07-08)Sensitive and specific visualisation of biomolecules in living models is highly challenging because of the complexity of cellular systems. Raman spectroscopy provides chemical contrast based upon molecular vibrations ...
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