Edinburgh Research Archive

• Improving our understanding of the in vivo modelling of psychotic disorders: a systematic review and meta-analysis 

  Bahor, Zsanett (The University of Edinburgh, 2018-11-30)

  Psychotic disorders represent a severe category of mental disorders affecting about one percent of the population. Individuals experience a loss or distortion of contact with reality alongside other symptoms, many of ...

• Role of Semaphorin3F in Neutrophilic inflammation 

  Plant, Tracie Marie (The University of Edinburgh, 2019-07-06)

  Effective host responses to injury and infection require both rapid recruitment of neutrophils into tissues and timely inflammation resolution. Research efforts have primarily focused separately on the initiation and ...

• Investigation of endoplasmic reticulum stress and protein aggregates in C9ORF72 mutant induced pluripotent stem cell-derived spinal motor neurons 

  Gane, Angus Buchanan (The University of Edinburgh, 2018-07-10)

  Introduction: Protein aggregations are pathological hallmarks of motor neuron disease (MND) and have been shown to cause activation of endoplasmic reticulum (ER) stress sensors. ER stress-induced pathways can lead to ...

• Clinical presentation and management of Paget’s disease of bone 

  Tan, Adrian (The University of Edinburgh, 2017-12-01)

  PDB is the second most common metabolic bone disease characterised by increased but disorganised bone remodelling. Some patients are asymptomatic but others present with bone pain or other complications such as fracture ...

• Investigating the role of UBR5, a ubiquitin-protein ligase of the N-end rule pathway, in skeletal tissue homeostasis 

  Kubiak, Malgorzata Maria (The University of Edinburgh, 2017-07-08)

  Using a conditional Ubr5 mutant (Ubr5mt) mouse the Ditzel lab identified a novel role for the ubiquitin-protein ligase UBR5 in maintaining articular cartilage (AC) homeostasis, suppressing osteoarthritis (OA) and controlling ...

• Promoting endothelialisation to reduce vascular injury following coronary angioplasty and stent implantation 

  Gallogly, Susan (The University of Edinburgh, 2017-12-01)

  Rationale and ObjectivesNew therapeutic approaches that promote repair of the vasculature following injury are necessary to improve the clinical outcomes in patients undergoing angioplasty and stenting for coronary artery ...

• Obesity and metforminin pregnancy 

  Chiswick, Carolyn Ann (The University of Edinburgh, 2017-07-08)

  Obesity is the most common antenatal comorbidity, affecting one in five of the antenatal population in the UK. It is associated with adverse outcomes for mother and baby in both the short and long term. Increasing data ...

• Effects of mutations in the eEF1A2 gene in mouse gene expression profiles and identification of potential markers for motor neuron degeneration 

  Qarkaxhija, Vesa (The University of Edinburgh, 2017-12-01)

  The elongation factor 1 alpha (eEF1A) exists in mammals as two highly conserved isoforms: eEF1A1 and eEF1A2 which share 98% amino acid sequence similarity. When bound with GTP, both forms recruit aminoacylated-tRNA for ...

• Strengthening health systems through eHealth: two mixed-methods case studies at 10 facilities in Malawi 

  Kawale, Paul (The University of Edinburgh, 2018-06-30)

  Background International agencies such as the World Health Organisation have highlighted the potential of digital information and communications technologies to strengthen health systems, which are underpinned by the ...

• Functional role of Vangl2 in bile duct injury 

  Wilson, David Hubert Livingstone (The University of Edinburgh, 2017-07-08)

  The Liver is comprised of hepatocytes, the parenchymal cells, and non-parenchymal cells which includes stellate cells, portal fibroblasts, inflammatory cells and cholangiocytes. Cholangiocytes are the epithelial cells ...

• Role of ISG15 in cancer 

  Crean, Clare (The University of Edinburgh, 2018-06-30)

  Interferon stimulated gene 15 (ISG15) is 165 amino acids in length and its protein is roughly 15kDa. ISG15 is a member of the ubiquitin-like family (Ubl) and shows homology to several regions of ubiquitin. The ISG15 ...

• Development of an in vitro assay for high-throughput screening investigating the role of mesenchymal stem cells on castration resistant prostate cancer cell growth 

  Williamson, Alexander James (The University of Edinburgh, 2018-06-30)

  Androgen deprivation therapy (ADT) can increase survival from prostate cancer by up to 2-3 years, but tumours invariably relapse into an ADT-unresponsive, incurable form, known as castrate resistant prostate cancer (CRPC). ...

• Identifying barriers to clinical trial participation with families affected by fragile X syndrome 

  Eley, Sarah Elizabeth Anne (The University of Edinburgh, 2017-12-01)

  Fragile x syndrome (FXS) is thought to be the most common inherited form of intellectual and developmental disability and the most common known single gene cause of autism. The prevalence of FXS is approximately 1.4 per ...

• Establishing methods for analysis of DNA methylation in breast cancer and cell-free circulating DNA 

  Domingo Sabugo, Clara (The University of Edinburgh, 2018-06-30)

  Breast cancer is the most common cancer in women worldwide. To date, diagnosis and metastasis monitoring are mainly carried out through tissue biopsy, a very invasive procedure limited only to certain locations and ...

• Investigating the role of miR-21 in autophagy and VMP1 

  O'Leary, Kate Marie (The University of Edinburgh, 2017-07-08)

  Previous work has identified a differentially methylated region (DMR) around the miR-21/VMP1 locus in IBD patients compared to HC and elevated levels of VMP1 and miR-21 have been detected in patients. MiR-21 is a microRNA ...

• DNA methylation variation in lean and obese placenta 

  Yang, Liu (The University of Edinburgh, 2017-12-01)

  One in five pregnant women is obese in the UK. Obesity in pregnancy is associated with risks of complications for the mother and child. Mechanisms linking maternal obesity with adverse outcomes for the offspring are not ...

• Defining the role and control of the lpxO gene in Klebsiella pneumoniae 

  Usher, Ben (The University of Edinburgh, 2017-12-01)

  Antimicrobial resistance (AMR) is fast becoming one of the greatest challenges to human mortality this century. In recent years the number of reported infections by multi-drug resistant (MDR) bacteria has seen a rapid ...

• Behaviour of single motor units in human skeletal muscle 

  Dasgupta, Anupam (The University of Edinburgh, 1962)

  In the first part it was shown that the firing frequencies of motor units at particular grades of isometric contraction depend on the total number of units available for recruitment and so are regulated by length and ...

• Observations on the toxic fractions of scarlatinal streptococci 

  Green, Cecil Alfred (The University of Edinburgh, 1941)

  1. Among a series of strains of haemolytic streptococci from thirty -five cases of scarlatina in the first week of illness, fourteen were found to correspond with one or other of Griffith's serological types, I, II, ...

• Gastro-intestinal nioplasia and its differential diagnosis 

  Somerville, [unknown] (The University of Edinburgh, 1962)

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