Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Neuronal circuits of experience-dependent plasticity in the primary visual cortex
(The University of Edinburgh, 2018-07-10)Our ability to learn relies on the potential of neuronal networks to change through experience. The primary visual cortex (V1) has become a popular system for studying how experience shapes cortical neuronal networks. ... -
Neuroepigenetics of preterm white matter injury
(The University of Edinburgh, 2018-06-30)Introduction: Preterm birth is increasing worldwide and is a major cause of neonatal death. Survivors are at increased risk of neurodisability, cognitive, social and psychiatric disorders in later life. Alterations to ... -
Novel applications of positron emission tomography in the non-invasive assessment of cardiovascular disease
(The University of Edinburgh, 2018-06-30)Introduction. Fused Positron Emission Tomography and Computed Tomography (PET/CT) is an emerging investigative tool in cardiovascular disease that provides an imaging-based quantification of pathophysiological processes ... -
Metabolic remodelling driven by MYC overexpression regulates the p53 tumour suppressor response
(The University of Edinburgh, 2018-06-30)The MYC onocogene is frequently overexpressed in human cancer due to its capacity to promote cell growth and cell proliferation. MYC overexpression activates the p53 tumour suppressor pathway, which resists the ... -
Metabolic programming in murine cytomegalovirus infected macrophages
(The University of Edinburgh, 2018-07-10)Immunity and metabolism have been viewed as separate fields, however recent evidence show that these two systems are intimately integrated, share resources and cross-regulate each other. Activated immune cells have to ... -
Mental health and spirituality of female prisoners in a women’s prison in Chile
(The University of Edinburgh, 2018-06-30)Background The mental health of prisoners is of growing global health importance as prison populations increase exponentially. Though additional risks of mental disorder and poor mental wellbeing of prisoners are now ... -
Lipoxin A4 on neutrophil reprogramming in bronchiectasis
(The University of Edinburgh, 2018-06-30)INTRODUCTION Bronchiectasis is a common chronic debilitating respiratory condition. Patients suffer daily cough, excess sputum production and recurrent chest infections because of inflamed and permanently damaged airways. ... -
Investigation of gene-environment interaction between Vitamin D and the colorectal cancer susceptibility genetic variant rs9929218
(The University of Edinburgh, 2018-06-30)Colorectal cancer (CRC) is common, with >1 million annual incidence worldwide and is associated with significant morbidity and mortality. Prevention is a particularly appealing strategy to combat CRC, but there is a ... -
Early characterisation of neurodegeneration with high-resolution magnetic resonance elastography
(The University of Edinburgh, 2018-06-30)This thesis contributes to recent interest within medical imaging regarding the development and clinical application of magnetic resonance elastography (MRE) to the human brain. MRE is a non-invasive phase-contrast MRI ... -
Kinematic alignment and total knee arthroplasty
(The University of Edinburgh, 2018-06-30)Osteoarthritis (OA) is one of the leading causes of global disability. Surgical intervention in the form of Total Knee Arthroplasty (TKA) has been established as an excellent treatment modality for people with OA who ... -
Investigation of the physiological roles of SRSF1-mediated translation
(The University of Edinburgh, 2018-06-30)The serine/arginine-rich (SR-) family proteins constitute a diverse group of pre-mRNA splicing factors that are essential for viability. They can be characterised based on the presence of one or two RRMs and an RS domain. ... -
Investigating the role of eosinophils in cardiac remodelling following myocardial infarction
(The University of Edinburgh, 2018-06-30)Myocardial infarction (MI) occurs following acute thrombotic occlusion of a coronary artery, and triggers a robust inflammatory response. Within hours, neutrophils are recruited to the infarcted myocardium followed by ... -
Investigating the function of VANGL2 in intestinal homeostasis & disease
(The University of Edinburgh, 2018-06-30)Introduction: Van Gogh-Like 2 (VANGL2) is a scaffolding planar cell polarity protein involved in non-canonical Wnt signalling. It has been shown to have crucial roles in regulating epithelial development and homeostasis. ... -
CRISPR/Cas9 genome-wide loss of function screening identifies novel regulators of reprogramming to pluripotency
(The University of Edinburgh, 2018-06-30)In 2006, Kazutoshi Takahashi and Shinya Yamanaka demonstrated the ability of four transcription factors; Oct4, Sox2, Klf4 and c-Myc to ‘reprogram’ differentiated somatic cells to a pluripotent state. This technology holds ... -
Investigating the role of thiosulfate sulfurtransferase in adipose tissue dysfunction in obesity
(The University of Edinburgh, 2018-06-30)Obesity is associated with dysfunction of adipose tissue due to oxidative stress and inflammation, leading to insulin resistance. Thiosulfate sulfurtransferase (Tst) was previously identified as an adipose-expressed ... -
Impairing hepatocyte regeneration to determine the regenerative capacity of the biliary epithelium
(The University of Edinburgh, 2018-06-30)Liver injury stimulates hepatocyte proliferation, regenerating the liver through self-replication. In cases where there is severe, repetitive, parenchymal damage, as seen in human chronic liver disease, hepatocyte mediated ... -
Identification of functional single nucleotide polymorphisms (SNPs) in High Risk-Human Papillomavirus (HR-HPV) related diseases
(The University of Edinburgh, 2018-06-30)Persistent infection of the cervix with high risk (HR) types of Human Papilloma Virus (HPV) (HR-HPV) can result in precancerous lesions and cancers. However, most HPV infections can be cleared naturally by the immune ... -
Integrated platform to assay melanoblast development in vitro
(The University of Edinburgh, 2018-06-30)Melanoblasts are the embryonic precursors of melanocytes, the pigment producing cells of the skin and hair. Melanoblasts are of key interest to developmental biologists for numerous reasons, including their ability to ... -
Cell-wide web of cytoplasmic nanocourses coordinates calcium signalling
(The University of Edinburgh, 2018-07-10)Ca2+ signals determine smooth muscle contraction and the switch from a contractile to a migratory-proliferative phenotype(s), which requires changes in gene expression. However, the mechanism by which different Ca2+ ... -
Investigating PSD-95 turnover at the synapse using the HaloTag technology
(The University of Edinburgh, 2018-06-30)PSD-95 is an abundant scaffolding protein found in the postsynaptic densities (PSDs) of excitatory synapses throughout the mammalian brain, and plays a critical role in innate and learned behaviours. PSD-95 assembles ...
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