Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Understanding in vivo modelling of depression
(The University of Edinburgh, 2019-11-25)Major Depressive Disorder (MDD) is the leading source of disability globally. Treatment-resistance among patients is common and even effective pharmacological therapies have a delayed effect on symptom relief. Better ... -
Investigating the role of the non-canonical inflammasome in senescence
(The University of Edinburgh, 2019-11-25)Cellular senescence is a permanent proliferative arrest of cells triggered by several different stress mechanisms. Senescent cells display an inflammatory phenotype termed the senescence-associated secretory phenotype ... -
Investigation of the tissue origins of cellfree DNA and candidate biomarkers for liquid biopsy
(The University of Edinburgh, 2019-11-25)Liquid biopsy is the sampling and analysis of analytes from various biological fluids to detect and diagnose cancer, for which it is an alternative to solid tissue biopsy for the detection of cancer. Compared to solid ... -
Role of exogenous Interleukin 4 in modulating the mononuclear phagocyte response to acute liver injury.
(The University of Edinburgh, 2019-11-25)Background Acute liver failure has significant mortality for which the only reliable treatment is transplantation. Murine models of acute liver injury are characterised by dramatic changes in the hepatic macrophage ... -
Helminth-derived inhibitors of the IL-33 pathway
(The University of Edinburgh, 2019-11-25)Allergic asthma is a chronic inflammatory disease of the airways characterised by type 2 immune responses in the lungs. Increased mucus production, airway hyperresponsiveness and eosinophilia are the main features of the ... -
Regulation of ageing by electrical synapses in the Nematode Caenorhabditis elegans
(The University of Edinburgh, 2019-11-25)Electrical synapses formed by gap junctions are abundant in nervous systems and critical for brain function. They allow not only the exchange of ions, but also of metabolites and second messengers and have been implicated ... -
Investigation of inflammatory and oxidative stress mechanisms in the disruption of white matter structure and function following chronic cerebral hypoperfusion
(The University of Edinburgh, 2019-11-25)Vascular cognitive impairment (VCI) describes a heterogeneous condition caused by cerebrovascular disease and disturbances in cerebral blood flow delivery. It is the second leading form of dementia and vascular factors ... -
Investigating the role of MyD88-NF-kB signalling in regulating the inflammatory response to the emerging pre-neoplastic cells
(The University of Edinburgh, 2019-11-25)Chronic inflammation has long been considered an enabling characteristic of the cancer microenvironment. The release of growth and survival factors, extracellular matrix-modifying enzymes and other bioactive molecules ... -
Potentially serious incidental findings in the UK Biobank Imaging Study
(The University of Edinburgh, 2019-11-25)The increased use of imaging across research, clinical and commercial contexts has generated debate and calls for evidence on the benefits and harms of incidental findings (defined as those which are unrelated to the ... -
Multi-modal retinal scanning for diagnostic and therapeutic biomarker discovery in neurodegenerative disease
(The University of Edinburgh, 2019-11-25)Purpose Investigate changes in retinal structure and function caused by multiple sclerosis (MS) using established and novel modes of image acquisition and analysis, in order to identify candidate biomarkers of disease. ... -
Editing the mouse genome to understand the regulation of milk proteins
(The University of Edinburgh, 2019-11-27)Dairy industries not only contribute to global food security but also have a major economic role worldwide. Milk is an important source of proteins, lactose, fat, and minerals, as such, understanding the genetic regulation ... -
Contribution of Lsh to DNA methylation during neurodevelopment
(The University of Edinburgh, 2019-11-25)DNA methylation is considered one of the oldest epigenetic modifications and is associated with repression of transcriptional activity. Embryonic development sees dynamic changes in this mark. Initially, widespread ... -
A computational approach to magnocellular oxytocin neuron dynamics
(The University of Edinburgh, 2019-11-25)Magnocellular oxytocin neurones, found mainly in the supraoptic nucleus and in the paraventricular nucleus of the hypothalamus, project their axons to the posterior pituitary, from where they secrete oxytocin into the ... -
Six cases
(The University of Edinburgh, 1921)Six cases: written for the Wightman Prize in Clinical Medicine, 1921 • I. A case of penile hypospadias; II. A case of diabetes insipidus; III. A case of carcinoma pylori; IV & V. 2 cases of diabetes mellitus; VI. A case ... -
Seasonal influenza vaccine effectiveness in asthma
(The University of Edinburgh, 2019-07-06)Introduction Influenza is a seasonal viral respiratory infection that causes considerable morbidity and mortality, particularly in individuals with chronic medical conditions such as asthma. Vaccination is one of the most ... -
Transcriptional and functional consequences of neuron-astrocyte interactions
(The University of Edinburgh, 2019-06-29)Astrocytes play a large number of roles essential for CNS health and are important mediators in CNS disease, demonstrating both neuroprotective and neurotoxic phenotypes. Non-cell autonomous interactions between neurons and ... -
Impact of genetic and environmental risk factors for schizophrenia on cortical brain structure
(The University of Edinburgh, 2019-07-06)It is now accepted that Schizophrenia, a neurodevelopmental disorder which affects around 1% of the population, is influenced by both genetic and environmental risk factors. Schizophrenia is evidenced as being heritable ... -
Breast cancer heterogeneity within the neoadjuvant window
(The University of Edinburgh, 2019-07-06)Breast cancer affects ~55,000 women in the UK annually. Key to the reliable management of the disease is robust characterisation of an individual’s tumour, to best determine the most appropriate treatment and likely ... -
Anxiety after stroke: intervention design and a randomised controlled trial
(The University of Edinburgh, 2019-07-06)INTRODUCTION: Anxiety is common and potentially debilitating after stroke. There is no reliable evidence to guide treatment. Barriers exist in accessing psychological care after stroke. Little is known about anxiety ... -
Interaction of host and viral microRNAs with infectious laryngotracheitis virus transcripts
(The University of Edinburgh, 2019-06-29)Infectious Laryngotracheitis Virus (ILTV) is an Alphaherpesvirus of the domesticated chicken and other economically important fowl such as pheasants, peafowl and turkeys. It causes an upper respiratory disease that is ...
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