Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Firefighters and acute myocardial infarction: understanding mechanisms and reducing risk
(The University of Edinburgh, 2018-11-30)Acute myocardial infarction is the commonest cause of death in firefighters, accounting for 45% of all deaths on duty. Compared with an average life expectancy of 77 years in the general population, the average age ... -
Distal radius fracture: relationships between psychological factors and recovery
(The University of Edinburgh, 2018-11-30)Distal radius fracture is a common injury. The majority of people recover well but a proportion have ongoing pain, stiffness, deformity and functional limitation. Associations between these outcomes, injury characteristics ... -
Targeting and repair of adult testicular somatic cells through viral gene therapy
(The University of Edinburgh, 2018-11-30)Androgens are essential for the maintenance of male health and wellbeing. A disturbance in androgen signalling has been associated with a number of clinically relevant disorders such as cardiovascular disease, diabetes ... -
Role of endothelin-1 in the renal handling of salt in early Type 1 diabetes mellitus
(The University of Edinburgh, 2018-11-30)Tight control of blood glucose and blood pressure (BP) reduces cardiovascular risk in early Type 1 diabetes mellitus (T1DM). Increased BP normally increases renal medullary perfusion and sodium excretion. This is called ... -
Translational assessment of cognitive impairments in depression models
(The University of Edinburgh, 2018-11-30)Major depressive disorder (MDD) affects 300 million people worldwide and is a major contributor to the global burden of disease. The aetiology of depression, emerging through a gene x environment interaction, is still ... -
Epigenetic regulation of heterochromatin structure and tumour progression
(The University of Edinburgh, 2018-11-30)Since the discovery of DNA packaging into chromatin, and McClintock’s (1951) work on position-effect variegation providing evidence of non-mendelian inheritance, the principal of a genome maintaining ‘on’ and ‘off’ states ... -
Effect of perinatal adversity on structural connectivity of the developing brain
(The University of Edinburgh, 2018-11-30)Globally, preterm birth (defined as birth at <37 weeks of gestation) affects around 11% of deliveries and it is closely associated with cerebral palsy, cognitive impairments and neuropsychiatric diseases in later ... -
Brain cortical variability, software, and clinical implications
(The University of Edinburgh, 2018-11-30)It is essential to characterize and quantify naturally occurring morphometric changes in the human brain when investigating the onset or progression of neurodegenerative disorders. The aim of this thesis is to characterize ... -
One Health approach to measure the impact on wellbeing of selected infectious diseases in humans and animals in Zambia
(The University of Edinburgh, 2018-11-30)This study describes the results of a cross-sectional survey conducted in Mambwe district in the Eastern Province in Zambia. It uses a One Health approach to assess the impact of veterinary, medical, environmental and ... -
Phenome wide association study of vitamin D genetic variants in the UK Biobank cohort
(The University of Edinburgh, 2018-11-30)Introduction Vitamin D status is an important public health issue due to the high prevalence of vitamin D insufficiency and deficiency, especially in high latitude areas. Furthermore, it has been reported to be associated ... -
Studying the synaptome: insights into ketamine action
(The University of Edinburgh, 2018-11-30)Major depressive disorder (MDD) is a growing health problem. Current treatment options are not always effective and take several weeks of regular administration before an improvement can be seen in symptoms. Sub-anaesthetic ... -
Sedentary behaviour in morbidly obese pregnant women
(The University of Edinburgh, 2018-11-30)Introduction Obesity during pregnancy is linked to many negative health effects for mothers and offspring. The majority of interventions with obese pregnant women based on physical activity have had limited success ... -
Role of 18F FDG PET/CT as a novel non-invasive biomarker of inflammation in chronic obstructive pulmonary disease
(The University of Edinburgh, 2018-11-30)A characteristic feature of Chronic Obstructive Pulmonary Disease (COPD) is an abnormal inflammatory response in the lungs to inhaled particles or gases. The ability to assess and monitor this response in the lungs of ... -
Early life risk factors for cerebrovascular disease and depressive symptoms in later life
(The University of Edinburgh, 2018-11-30)Cerebrovascular disease (CVD) can result in cerebral small vessel disease (cSVD) and structural brain changes such as decreased cortical volume, brain atrophy and cerebral infarcts which are major causes of stroke and ... -
Mitochondrial damage-associated molecular patterns (DAMPs) in inflammatory bowel disease
(The University of Edinburgh, 2018-11-30)Background The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn’s disease (CD) are chronic relapsing inflammatory disorders which have a rising incidence and cause significant morbidity. There are ... -
Matrix signalling and hippocampal neurogenesis
(The University of Edinburgh, 2018-11-30)The adult mammalian brain harbours at least two germinal - or neurogenic - niches in which new neurons are born throughout life. These neurogenic niches comprise the subependymal zone which lines the ventricular system, ... -
Improving the risk stratification, diagnosis and classification of patients with suspected myocardial infarction
(The University of Edinburgh, 2018-11-30)Myocardial infarction is a leading cause of morbidity and mortality worldwide. The purpose of this thesis was to develop strategies for the assessment of patients with suspected myocardial infarction using a high-sensitivity ... -
CSPG4 in osteosarcoma: functional roles and therapeutic potential
(The University of Edinburgh, 2018-11-30)Osteosarcoma is the most common primary malignancy of bone. 5-year survival has remained stable at around 60-70% for 40 years. However, a number of patients will suffer from recurrent and/or metastatic disease representing ... -
Regulation of intestinal regulatory T cells by prostaglandin E₂
(The University of Edinburgh, 2018-11-30)Pathogenesis of autoimmune and auto-inflammatory diseases is induced by auto-aggressive helper T (Th) cells (i.e. Th1 and Th17 cells), and can be controlled by regulatory T cells (Tregs) characterized by expression of ... -
Mitochondrial dynamics in demyelinated axons in a cerebellar slice culture system
(The University of Edinburgh, 2018-11-30)Axonal degeneration is the major cause of disability in progressive multiple sclerosis (MS). It has been shown that in MS and relevant disease models, demyelinated axons harbor an increased number of mitochondria, which ...
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