Edinburgh Research Archive

• Investigation of synaptic dysfunction in Alzheimer’s disease 

  Jackson, Rosemary Joan (The University of Edinburgh, 2018-07-10)

  Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ...

• Identification and study of a role for toll-like receptors in oncogene-induced senescence 

  Hari, Priya (The University of Edinburgh, 2018-06-30)

  Oncogene-induced senescence (OIS) is a fail-safe mechanism activated to halt the proliferation of cells at risk of malignant transformation. It is a cell cycle arrest program of biological changes to the cell comprising ...

• Contribution of Lsh to DNA methylation reprogramming in embryonic stem cell, epiblast stem cell and embryoid body model systems 

  Revuelta, Ailsa Clare (The University of Edinburgh, 2018-06-30)

  DNA methylation is a key epigenetic mark which undergoes global reprogramming during early mammalian embryonic development, resulting in almost complete erasure of the mark after fertilisation of the zygote. Genome-wide ...

• mCCDcl1 cells exhibit a transitional phenotype: implications for collecting duct plasticity 

  Assmus, Adrienne Madeleine (The University of Edinburgh, 2018-06-30)

  The cortical collecting duct of the mammalian kidney plays a critical role in the regulation of body volume, sodium pH and osmolarity and is composed of two distinct cells types, principal cells and intercalated cells. ...

• Understanding tumour suppressive responses upon inhibition of ribosome maturation 

  Pantazi, Asimina (The University of Edinburgh, 2018-06-30)

  Ribosome biogenesis is an essential biological process that is required for cell division and growth. Cancer cells alter their physiology in order to meet their excessive growth demands and therefore maintain ...

• Role of transcription factor Pax6 in the development of the ventral lateral geniculate nucleus 

  Li, Ziwen (The University of Edinburgh, 2018-07-10)

  The development of the diencephalon can be summarised as a process in which cells that initially appear similar give rise to a complex structure that contains a variety of cell groups called nuclei. It involves two stages: ...

• Role of physical activity in daily life in Chronic Obstructive Pulmonary Disease (COPD) 

  Mantoani, Leandro Cruz (The University of Edinburgh, 2018-06-30)

  Background: Chronic obstructive pulmonary disease (COPD) is an important common chronic lung condition that is a leading cause of morbidity and mortality worldwide, resulting in a substantial and increasing economic and ...

• Role of DNA methylation and Polycomb machineries in directing higher-order chromatin architecture in embryonic stem cell 

  McLaughlin, Kathryn Anne (The University of Edinburgh, 2018-06-30)

  Mouse embryonic stem cells (mESCs) are an excellent model to study epigenetics and chromatin structure, owing to their self-renewal capabilities and tolerance of dynamic changes to DNA and histone modifications. Culturing ...

• Metabolic basis of MYC-induced apoptosis 

  Su, Huizhong (The University of Edinburgh, 2018-06-30)

  Programmed cell death, known as apoptosis, is widely accepted as a key tumour suppression mechanism. The oncogene MYC promotes cell growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic ...

• Eye as a window to the brain: investigating the clinical utility of retinal imaging derived biomarkers in the phenotyping of neurodegenerative disease. 

  Cameron, James R. (The University of Edinburgh, 2018-06-30)

  Background Neurodegenerative diseases, like multiple sclerosis, dementia and motor neurone disease, represent one of the major public health threats of our time. There is a clear persistent need for novel, affordable, ...

• Effect that the t(1;11) translocation and mental disorders have on glutamate and NAA levels in the prefrontal lobe, as measured by MRS 

  Watson, Andrew (The University of Edinburgh, 2018-06-30)

  1H-Magnetic Resonance Spectroscopy (MRS) is a MRI paradigm that allows the levels of specific metabolites to be estimated in vivo [1]. This means that insights into the biochemical changes associated with a rare genetic ...

• Tacrolimus pharmacogenomics in abdominal solid organ transplantation 

  Falconer, Stuart John (The University of Edinburgh, 2018-06-30)

  Background: Abdominal solid organ transplantation has evolved from an experimental procedure to a well-established therapy within a few decades. This success is largely due to the introduction of calcineurin inhibitor ...

• Synaptome mapping of the postsynaptic density 95 protein in the human brain 

  Curran, Olimpia Elwira (The University of Edinburgh, 2018-06-30)

  The past three decades of synaptic research have provided new insights into synapse biology. While synapses are still considered the fundamental connectors between the nerve cells in the central nervous system, they are ...

• Synaptic vesicle recycling in preclinical models of intellectual disability, autism spectrum disorder and epilepsy 

  Bonnycastle, Katherine (The University of Edinburgh, 2018-07-10)

  The development of the central nervous system is dysregulated in neurodevelopmental disorders such as intellectual disability, autism spectrum disorder, and epilepsy. These three disorders have different clinical features, ...

• Synapse dysfunction in Alzheimer’s disease: contributions of amyloid-beta and tau 

  Pickett, Eleanor Kay (The University of Edinburgh, 2018-07-10)

  Alzheimer's disease (AD) is characterised by memory loss, insidious cognitive decline, profound neurodegeneration, and the extracellular accumulation of amyloid-beta (Aβ) peptide in senile plaques and intracellular ...

• Development of acoustic tissue mimicking materials for preclinical ultrasound imaging applications 

  Rabell Montiel, Adela (The University of Edinburgh, 2018-06-30)

  Many applications of ultrasound test phantoms require that the acoustical properties of the phantom should closely match those of soft tissue. Numerous commercial test phantoms of this type are available for use with ...

• Studying the ability of finding single and interaction effects with Random Forest, and its application in psychiatric genetics 

  Neira Gonzalez, Lara Andrea (The University of Edinburgh, 2018-06-30)

  Psychotic disorders such as schizophrenia and bipolar disorder have a strong genetic component. The aetiology of psychoses is known to be complex, including additive effects from multiple susceptibility genes, interactions ...

• Strengthening health systems through eHealth: two mixed-methods case studies at 10 facilities in Malawi 

  Kawale, Paul (The University of Edinburgh, 2018-06-30)

  Background International agencies such as the World Health Organisation have highlighted the potential of digital information and communications technologies to strengthen health systems, which are underpinned by the ...

• Synaptic vesicle protein 2A-dependent function and dysfunction at the presynapse 

  Low, Darryl Weijun (The University of Edinburgh, 2018-07-10)

  Neurotransmission is essential for neuronal communication. At the presynapse, synaptic vesicles (SVs) undergo exocytosis to release neurotransmitter in response to incoming action potentials, and endocytosis to maintain ...

• Regional brain volumes and antidepressant treatment resistance in major depressive disorder 

  Wigmore, Eleanor May (The University of Edinburgh, 2018-06-30)

  Major depressive disorder (MDD) is a heritable and highly debilitating condition with antidepressants, first-line treatment, demonstrating low to modest response rates. No current biological mechanism substantially ...

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