Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Studies on the interaction of cholesterol analogues with cholesterol oxidising systems and membrane components
(The University of Edinburgh, 1979)A series of cholesterol analogues possessing side chains with either more or less carbon atoms than cholesterol were synthesised from hyodesoxycholic acid and fully characterised by nuclear magnetic resonance, mass ... -
Kneeling function following total knee arthroplasty
(The University of Edinburgh, 2018-11-30)The ability to kneel is an important function of the knee joint, as it is required for many daily activities, including religious practices, professional occupations and recreational pursuits. The inability to kneel ... -
11β-hydroxysteroid dehydrogenase type I inhibition in solid tumours
(The University of Edinburgh, 2018-06-30)Glucocorticoids, key hormonal regulators of the stress response, powerfully influence inflammation and metabolism. Reducing excessive glucocorticoid exposure is beneficial in treating metabolic and cognitive disorders, ... -
Contributions of cortisol and corticosterone to metabolic regulation in humans
(The University of Edinburgh, 2018-11-30)Both cortisol and corticosterone circulate in human plasma however corticosterone has been relatively neglected in human research to date. There is evidence of distinct regulation within different tissues with the ... -
Development of a modular in vivo reporter system for CRISPR-mediated genome editing and its therapeutic applications for rare genetic respiratory diseases
(The University of Edinburgh, 2018-11-30)Rare diseases, when considered as a whole, affect up to 7% of the population, which would represent 3.5 million individuals in the United Kingdom alone. However, while “personalised medicine” is now yielding remarkable ... -
Collective social capital: a study of new public health and end-of-life care
(The University of Edinburgh, 2018-11-30)Background: An appreciation of the broader social determinants of health and wellbeing has led to the inclusion of new public health principles and practice within health and social care. End-of-life care has been no ... -
Influence of early life and positive affect on feeding behaviour and food choice in the rat
(The University of Edinburgh, 2018-11-30)In recent years, worldwide obesity rates have risen dramatically, putting major strain on public health systems and the economy. Obesity is a multifaceted disease and its development can be influenced by a variety of ... -
Metabolic and vascular effects of thiosulfate sulfurtransferase deletion
(The University of Edinburgh, 2018-11-30)Hydrogen sulfide (H2S), is a gasotransmitter with several key roles in metabolism and vascular function. The effects of H2S are dependent on concentration and target organ. For example, increased H2S concentrations impair ... -
Role of WT1 in Ischaemic Angiogenesis
(The University of Edinburgh, 2018-11-30)Ischaemia causes irreversible tissue damage in cardiovascular disease. Since regenerative angiogenesis fails to consistently induce sufficient reperfusion to facilitate repair, targeted manipulation of angiogenesis is ... -
Role of SVEP1 in fibrosis, metabolism and blood pressure
(The University of Edinburgh, 2018-06-30)Sushi, von Willebrand factor type A, epidermal growth factor and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein which may bind to cell surface molecules such as integrins. A non-synonymous single ... -
Regulatory mechanisms and biological implications of protein complex assembly
(The University of Edinburgh, 2018-06-30)Every living organism possesses a genome that contains within it a unique set of genes, a substantial number of which encode proteins. Over the last 20 years, it has become apparent that organismal complexity arises not ... -
Architecture of human complex trait variation
(The University of Edinburgh, 2018-06-30)A complex trait is a trait or disease that is controlled by both genetic and environmental factors, along with their interactions. Trait architecture encompasses the genetic variants and environmental causes of variation ... -
Developing, refining and feasibility study of mobile app to support asthma self-management (A4A - APP for Asthma).
(The University of Edinburgh, 2018-11-30)Background: Self-management with an action plan, as opposed to passive self-monitoring, improves health outcomes. However, engaging patients is challenging. Mobile technology, incorporating education, personalised asthma ... -
Investigating the Influence of CDK11 in developmental and cancer phenotypes
(The University of Edinburgh, 2018-11-30)Cyclin-Dependent Kinase 11 (CDK11) is a serine/threonine kinase encoded at human locus 1p36.3 by two paralogous genes CDK11A and CDK11B. CDK11 has diverse roles in the regulation of transcription, splicing, apoptosis ... -
Developmental genetic analysis of post-axial longitudinal limb reduction defect (PALLRD) in Miller syndrome and nonclassical Miller syndrome
(The University of Edinburgh, 2018-06-30)This project aimed to provide a greater understanding of limb development through the characterisation of Mendelian disorders. The more specific aim was to identify the developmental basis of the Post Axial Longitudinal ... -
New care home admission following acute hospitalisation: a mixed methods approach
(The University of Edinburgh, 2018-11-30)Care home admission following acute hospitalisation is a lived reality across Scotland, experienced by over 8,000 people annually. The aim of this thesis was to develop an understanding of new care home admission following ... -
Modulation of OPC migration: improving remyelination potential in multiple sclerosis
(The University of Edinburgh, 2018-11-30)In the brain, axons are wrapped by myelin sheaths which ensure fast saltatory conduction of impulses and provide metabolic support. In multiple sclerosis (MS), the myelin sheaths are lost which leaves the axon denuded. ... -
Protein secretion and encystation in Acanthamoeba
(The University of Edinburgh, 2018-11-30)Free-living amoebae (FLA) are protists of ubiquitous distribution characterised by their changing morphology and their crawling movements. They have no common phylogenetic origin but can be found in most protist evolutionary ... -
Markers of iron status and cardiometabolic disease risk: an exploration of the association based on cross-sectional and prospective studies in multiple populations
(The University of Edinburgh, 2017-12-01)The aim of this thesis is to contribute to the understanding of iron metabolism, as a factor associated with cardiometabolic risk, by undertaking secondary data analyses. The objectives were to identify gaps in existing ... -
Exploring the role of Kindlin-1 in skin homeostasis and squamous cell carcinoma
(The University of Edinburgh, 2017-07-08)Kindlin-1 (Kin1) is an epithelial focal adhesion protein that plays a key role in integrin-mediated anchorage of cells to the extracellular matrix. Congenital loss of Kin1 leads to Kindler ...
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