Edinburgh Research Archive

• Characterising the role of TLE1 in Crohn’s disease 

  Sharma, Nidhi (The University of Edinburgh, 2016-07-02)

  The inflammatory bowel diseases (IBD) are chronic, relapsing and remitting diseases of the gastrointestinal tract. There are two main types of IBD: Crohn’s disease (CD) and ulcerative colitis (UC). The prevalence of IBD ...

• Statistical evaluation of surrogate outcomes: methodological extensions to ordinal outcomes with applications in acute stroke 

  Ensor, Hannah Margaret (The University of Edinburgh, 2016-11-29)

  Background Surrogate outcomes are measures of treatment effect that can be used to predict treatment effect on the true outcome of interest. Surrogates are valued as they can be used in place of true outcomes to reduce ...

• Role of severe obesity in osteoarthritis 

  Harasymowicz, Natalia Sara (The University of Edinburgh, 2016-11-29)

  Osteoarthritis (OA) is the most common degenerative joint disease affecting more than 40% of people above the age of 65 (Neogi et al., 2013). Obesity is one of the main risk factors of OA and has become a major problem ...

• Measurement of subtle blood-brain barrier disruption in cerebral small vessel disease using dynamic contrast-enhanced magnetic resonance imaging 

  Heye, Anna Kathrin (The University of Edinburgh, 2016-11-29)

  Cerebral small vessel disease (SVD) is a common cause of strokes and dementia. The pathogenesis of SVD is poorly understood, but imaging and biochemical investigations suggest that subtle blood-brain barrier (BBB) leakage ...

• Systematic review and meta-analysis of the effects of treatment and immunization against schistosomiasis 

  Fukushige, Mizuho (The University of Edinburgh, 2016-11-29)

  Schistosomiasis is a water-borne parasitic disease of great public health importance mainly in sub-Saharan African countries. The majority of current control programmes use the antihelminthic drug praziquantel to reduce ...

• Quantification of cardiac magnetic resonance imaging perfusion in the clinical setting at 3T 

  Papanastasiou, Georgios (The University of Edinburgh, 2016-11-29)

  Dynamic contrast enhanced (DCE) cardiac magnetic resonance imaging (MRI) is well-established as a non-invasive method for qualitatively detecting obstructive coronary artery disease (CAD) which can impair myocardial blood ...

• Importance of poly(A)-binding protein 4 (PABP4) in healthy pregnancy 

  Hrabálková, Lenka (The University of Edinburgh, 2016-11-29)

  Healthy pregnancy requires a tightly regulated materno-fetal dialogue for processes such as embryo implantation, endometrial decidualisation (in the mouse), placentation and maternal adaptation to occur. Disruption of ...

• Cell-lineage-specific chromosomal instability in condensin II mutant mice 

  Woodward, Jessica Christina (The University of Edinburgh, 2016-11-29)

  In order to equally segregate their genetic material into daughter cells during mitosis, it is essential that chromosomes undergo major restructuring to facilitate compaction. However, the process of transforming diffuse, ...

• Cardiovascular effects of the sirtuin and urocortin systems in humans 

  Venkatasubramanian, Sowmya (The University of Edinburgh, 2016-11-28)

  Background Cardiovascular disease continues to remain a leading cause of morbidity and mortality in both developing and developed worlds. The sirtuin and urocortin systems are novel hormone systems in humans with an ...

• Development of registration methods for cardiovascular anatomy and function using advanced 3T MRI, 320-slice CT and PET imaging 

  Wang, Chengjia (The University of Edinburgh, 2016-11-29)

  Different medical imaging modalities provide complementary anatomical and functional information. One increasingly important use of such information is in the clinical management of cardiovascular disease. Multi-modality ...

• Prevalence and treatment of obstructive sleep apnoea/hypopnoea syndrome in adults with Down syndrome 

  Hill, Elizabeth Anne (The University of Edinburgh, 2016-11-29)

  Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is characterised by repeated cycles of upper airway obstruction during sleep, leading to diurnal symptoms. Individuals with Down syndrome (DS) are predisposed to this ...

• Design and application of SuRFR: an R package to prioritise candidate functional DNA sequence variants 

  Ryan, Niamh Margaret (The University of Edinburgh, 2016-11-29)

  Genetic analyses such as linkage and genome wide association studies (GWAS) have been extremely successful at identifying genomic regions that harbour genetic variants contributing to complex disorders. Over 90% of ...

• Role of systemic inflammation in cerebral small vessel disease. 

  Wiseman, Stewart John (The University of Edinburgh, 2016-11-29)

  Cerebral small vessel disease (SVD) is a distinct microvascular disorder that can lead to lacunar stroke, an important stroke subtype that accounts for a quarter of all ischaemic strokes. SVD is associated with imaging ...

• Investigating the functional role of SMOC-1 in zebrafish 

  Sexton, David James (The University of Edinburgh, 2016-07-02)

  True anophthalmia is the most severe congenital eye malformation. With absence of the eye, optic nerve, chiasm and optic tracts. Identifying the genes that cause genetic true anophthalmia should improve our understanding ...

• Unravelling higher order chromatin organisation through statistical analysis 

  Moore, Benjamin Luke (The University of Edinburgh, 2016-07-02)

  Recent technological advances underpinned by high throughput sequencing have given new insights into the three-dimensional structure of mammalian genomes. Chromatin conformation assays have been the critical development ...

• Characterisation and segmentation of basal ganglia mineralization in normal ageing with multimodal structural MRI 

  Glatz, Andreas (The University of Edinburgh, 2016-07-02)

  Iron is the most abundant trace metal in the brain and is essential for many biological processes, such as neurotransmitter synthesis and myelin formation. This thesis investigates small, multifocal hypointensities that ...

• Development of finite element analysis of magnetic resonance elastography to investigate its potential use in abdominal aortic aneurysms 

  Hollis, Lyam Mark (The University of Edinburgh, 2016-07-02)

  Abdominal aortic aneurysm (AAA) is a form of cardiovascular disease whereby a change in the material properties of the vessel wall results in a localised dilation of the abdominal aorta. The primary risk of AAAs is rupture ...

• Chondrogenic potential of perivascular stem cells from the infra-patellar fat pad 

  Hindle, Paul (The University of Edinburgh, 2016-07-02)

  Articular cartilage damage and degeneration is a siginficant clinical problem which no technique has been able to adequately and reliably repair or regenerate. Recent research has investigated the use of cell-based ...

• Glucocorticoids and the diurnal rhythm of NCC phosphorylation: implications for blood pressure control 

  Ivy, Jessica Ruth (The University of Edinburgh, 2016-07-02)

  Reabsorbing ~7% of the sodium load, the distal convoluted tubule plays key roles in blood pressure (BP) homeostasis. Here, Na-Cl co-transport (NCC) is the major route for apical Na entry making thiazide diuretics (NCC ...

• Cortisol and inflammation in delirium and long-term cognitive decline after hip fracture 

  Hall, Roanna Jane (The University of Edinburgh, 2016-07-02)

  Delirium, or “acute confusion” is a common and serious acute neuropsychiatric syndrome mainly affecting older people. It is associated with multiple adverse outcomes, including an increased risk of developing dementia ...

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