Edinburgh Research Archive

• Improving radiotherapy using image analysis and machine learning 

  Montgomery, Dean (The University of Edinburgh, 2016-11-29)

  With ever increasing advancements in imaging, there is an increasing abundance of images being acquired in the clinical environment. However, this increase in information can be a burden as well as a blessing as it may ...

• Direction of cellular protrusions by curvature 

  Martin, Kimberly Cordwint (The University of Edinburgh, 2017-07-07)

  Developmental processes involving symmetry-breaking of homogeneous cell populations into leaders and followers are found in many important contexts. Cells constrained by culture on two-dimensional scaffolds, as well as ...

• Investigating novel therapeutic approaches and targets to prevent synapse degeneration 

  Amorim, Ines Da Silva (The University of Edinburgh, 2017-07-07)

  Neurodegenerative diseases are associated with extensive physical and mental debilitation, significant costs to the healthcare system, as well as great emotional and financial burden to the patients, their families and ...

• Functional consequences of mutations in GRIN2A and GRIN2B associated with mental disorders 

  Marwick, Katherine Freda McEwan (The University of Edinburgh, 2017-07-07)

  GRIN2A and GRIN2B encode the GluN2A and GluN2B subunits of the NMDA receptor, a subtype of ionotropic glutamate receptor that displays voltage-dependent block by Mg2+ and a high permeability to Ca2+. These receptors play ...

• Economic analysis of zoonotic disease control in Uganda and the Lao People’s Democratic Republic 

  Okello, Walter Otieno (The University of Edinburgh, 2017-07-07)

  Background: Despite the acknowledged importance of economic assessments for public health interventions at the human-animal-ecosystem interface, there are currently limited economic methodologies for doing so. In this ...

• Investigation into the destructive and adaptive responses of neural cells to stress 

  Hasel, Philip (The University of Edinburgh, 2017-07-07)

  Homeostasis within the neuro-glial unit is essential to the longevity of neurons. Conversely, loss of homeostasis, particularly of Ca2+ levels, of redox balance and of ATP, contribute to neuronal loss and dysfunction in ...

• Immune regulation induced by apoptotic cells in health and in systemic lupus erythematosus (SLE) 

  Simpson, Joanne Elizabeth (The University of Edinburgh, 2016-07-02)

  Systemic lupus erythematosus (SLE) is a chronic autoimmune disease where failure to remove apoptotic cells, due to a defect in phagocytic cells, or deficient opsonisation, leads to secondary necrosis and the release of ...

• Post-GWAS functional characterisation of colorectal cancer risk loci 

  Ooi, Li Yin (The University of Edinburgh, 2016-07-02)

  Large bowel cancer, or colorectal cancer (CRC) is the third most common cause of cancer worldwide and the fourth biggest cause of cancer mortality. Twin studies have shown that the heritable contribution is ~35%, with ...

• Relaxin as a therapeutic haemodynamic modulator in liver disease 

  Snowdon, Victoria Katherine (The University of Edinburgh, 2016-07-02)

  Introduction: Hepatorenal syndrome (HRS) is a common complication of advanced cirrhosis with a high mortality rate and limited treatment options. Central to its pathogenesis is severe, but potentially reversible, renal ...

• Optogenetic dissection of the dopaminergic circuitry involved in memory consolidation 

  Duszkiewicz, Adrian Jacek (The University of Edinburgh, 2016-06-27)

  The ‘synaptic tagging-and-capture’ (STC) theory of cellular memory consolidation holds that memory persistence can be altered by prior or subsequent patterns of neural activity (Redondo & Morris 2011). The aim of this ...

• Proximal forearm fractures: epidemiology, functional results and predictors of outcome 

  Duckworth, Andrew David (The University of Edinburgh, 2016-07-02)

  Proximal forearm fractures account for over 10% of all upper limb fractures. There is limited epidemiological data available and much of the literature focuses on the more complex fracture patterns, with the role of ...

• Role of cyclin-dependent kinase 9 in the resolution of innate inflammation in a zebrafish tailfin injury model 

  Hoodless, Laura Jane (The University of Edinburgh, 2016-07-02)

  Neutrophils are an important cell in host defence and migrate rapidly to sites of inflammation when the host is compromised (e.g., in infection or wounding). There, they produce and/or release inflammatory mediators ...

• HOT study: the development, management and results from phase IIB, randomised controlled trial of heme arginate in recipients of deceased donor renal transplants 

  Thomas, Rachel Alexandra Barclay (The University of Edinburgh, 2016-07-02)

  Aims There are few proven therapies that can protect against the inevitable ischaemia reperfusion injury (IRI) that occurs during renal transplantation. IRI increases the likelihood of delayed graft function (DGF), which ...

• Natriuretic peptides in valvular heart disease 

  Sharma, Vishal (The University of Edinburgh, 2016-07-02)

  Plasma natriuretic peptide concentrations rise in response to either atrial or ventricular wall stretch and have been found to be useful in the diagnosis and assessment of patients with congestive cardiac failure. Although ...

• Role of hypochlorous acid (HOCl) in sodium chloride-induced inhibition of virus replication 

  Cai, Baiyi (The University of Edinburgh, 2016-06-27)

  There is evidence to suggest hypertonic saline (NaCl solution) could improve symptoms and reduce hospital stay in patients with viral respiratory tract infections (VRTI) such as bronchiolitis and chronic rhinosinusitis. ...

• Chemical genetics in zebrafish: modulation of cAMP and MAPK pathways in behaviour 

  Lundegaard, Pia Rengtved (The University of Edinburgh, 2016-07-02)

  The prevalence of stress and anxiety disorders in modern society is increasing, but the development of new treatments decreasing due to high research costs and low success rates in clinical trials. The latest type of ...

• Exploring the roles of inputs to hippocampal area CA1 

  Allison, Elizabeth Anastasia Margaret Alice (The University of Edinburgh, 2016-06-27)

  Place cells in the hippocampus fire in specific locations within an environment. The aim of this thesis is to investigate the different inputs to the hippocampus and what they contribute to place cell activity and ...

• Investigating the differential instructive roles of WT1's isoforms 

  Petrovich, Giulia (The University of Edinburgh, 2016-07-02)

  The Wilms' tumour suppressor gene Wt1 is a key regulator of embryonic development and tissue homeostasis. In humans, mutation in the gene may lead to childhood kidney cancer, severe glomerular kidney diseases, gonadal ...

• MicroRNA regulation of drug metabolism in stem cell - derived hepatocytes 

  Szkolnicka, Dagmara Maria (The University of Edinburgh, 2016-07-02)

  The liver is a multi-functional and highly regenerative organ. While resilient, the liver is susceptible to organ damage and failure. In both the acute and chronic settings liver disease has dire consequences for health. ...

• Role of B cells in a mouse model of renal transplantation 

  Tse, George Hondag (The University of Edinburgh, 2016-07-02)

  Renal transplantation is the optimum treatment for end-stage renal failure. B cells have been identified in chronic allograft damage (CAD) and are associated with the development of tertiary lymphoid tissue within the ...

View more