Now showing items 1-2 of 2

  • 1,2,4,5-Tetrazine mediated decaging of biologically relevant molecules 

    Jain, Sarthak (The University of Edinburgh, 2016-11-29)
    Many cancer drugs are inherently cytotoxic, leading to severe toxicity towards healthy tissues and organs. One effective strategy to circumvent these side effects is to mask a cytotoxic drug with a “caging group” which, ...
  • Towards novel 1,2,4,5-Tetrazine mediated peptide macrocyclisations 

    Harwood, Iain David (The University of Edinburgh, 2016-06-28)
    Interest in linear peptides and peptidomimetics experienced rapid growth within the pharmaceutical industry due to their ability to disrupt protein-protein interactions; and their ability to modulate protein function by ...