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Please use this identifier to cite or link to this item:
http://hdl.handle.net/1842/702
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| Title: | Ageing: Cognitive change and the APOEe4 allele |
| Authors: | Deary, Ian J
Whiteman, Martha C
Pattie, Alison
Starr, John M
Hayward, Caroline
Wright, Alan F
Carothers, Andrew
Whalley, Lawrence J |
| Issue Date: | 29-Aug-2002 |
| Citation: | Deary IJ, Whiteman MC, Pattie A, Starr JM, Hayward C, Wright AF, Carothers A, Whalley LJ, NATURE, 418 (6901): 932-932 AUG 29 2002 |
| Publisher: | Nature Publishing Group |
| Abstract: | There is a marked variation in whether
people retain sufficient cognitive
function to maintain their quality of
life and independence in old age, even
among those without dementia, so it
would be valuable to identify the determinants
of normal age-related cognitive
change (1,2). We have retested non-demented
80-year-olds who were participants in the
Scottish Mental Survey of 1932, and find
that the variation in their non-pathological
cognitive change from age 11 to 80 is related
to their apolipoprotein E (APOE) genotype.
This effect of the APOEe4 allele on
normal cognitive ageing may be mediated
by a mechanism that is at least partly independent
of its predisposing effect towards
Alzheimer’s disease. |
| Keywords: | Cognitive
apolipoprotein E
APOEe4
allele
ageing
dementia
demented
Alzheimer’s disease |
| URI: | http://www.nature.com/
http://hdl.handle.net/1842/702 |
| Appears in Collections: | Psychology research publications
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