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|Title: ||Direct Arylation of Thiazoles|
|Authors: ||Turner, Gemma L|
|Supervisor(s): ||Greaney, Michael F|
|Issue Date: ||2009|
|Publisher: ||The University of Edinburgh|
|Abstract: ||An introduction to the thiazole ring system is presented together with a detailed, but
non-exhaustive review of the rapidly emerging area of palladium-mediated directed
The direct arylation of thiazole is also discussed together with our attempts to
improve the established methods. A high-yielding, mild protocol has been developed
for the functionalisation of the most electron-rich carbon-hydrogen bonds in a
number of heterocyclic ring systems, this represents the first example of a C-H
activation reaction being accomplished in aqueous media and allows access to a
diverse range of functionalised aryl heterocycles.
In addition, work towards functionalisation of the thiazole C4 position is described.
A number of different approaches are discussed and our endeavors are recorded.|
|Appears in Collections:||Chemistry thesis and dissertation collection|
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